Publications by authors named "Abir Lefsay"
Article Synopsis
- CHKB is a gene that codes for an enzyme crucial for producing phosphatidylcholine, a key component of cell membranes.
- Inactivating this gene in mice leads to a type of muscular dystrophy, but intriguingly, levels of phosphatidylcholine don’t significantly change throughout the disease.
- The study shows that affected muscles initially struggle to break down fatty acids for energy, which leads to an increase in fat storage; however, using specific treatments can help restore energy production and protect muscle cells from damage.
The CHKB gene encodes choline kinase β, which catalyzes the first step in the biosynthetic pathway for the major phospholipid phosphatidylcholine. Homozygous loss-of-function variants in human CHKB are associated with a congenital muscular dystrophy. Dilated cardiomyopathy is present in some CHKB patients and can cause heart failure and death.
View Article and Find Full Text PDFSynthesis and tandem mass spectrometry of chlorinated triacylglycerols.
Chem Phys Lipids
September 2013
The incorporation of 9,10-dichlorooctadecanoyl groups using enzyme-catalyzed acylation and protecting group strategies yielded specific regioisomers of di- and tetrachlorinated triacylglycerols. Hexachloro- and hexabromotriacylglycerols were synthesized by addition of chlorine or bromine to tri-(cis-9-octadecenoyl)glycerol. Upon electrospray ionization and tandem mass spectrometry, the sodium adduct ions of all compounds containing a 9,10-dichlorooctadecanoyl group readily lost two molecules of HCl when subjected to collision-induced dissociation.
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