Low Dose of Nickel and Benzo [a] Anthracene in Rat-Diet, Induce Apoptosis, Fibrosis, and Initiate Carcinogenesis in Liver via NF-Ƙβ Pathway.

Environmental contaminants such as polycyclic aromatic hydrocarbon (PAH) and heavy metals are major contaminants of food such as fish thus serving as source of exposure to human. This study was designed to evaluate the carcinogenic risk and other risks associated with long-term consumption of environmentally relevant dose of nickel and benzo [a] anthracene in rats. Thirty-six (36) male rats weighing between 80 and 100 g were assigned into 6 groups of 6 animals each; normal, nickel-, and benzo [a] anthracene-exposed groups for 12 and 24 weeks, respectively.

Evaluation of long-term effects of nickel and benzo [a] anthracene contaminated diets in rats' kidney; mimicking human exposure from food.

Objectives: Accumulative effects of heavy metals and polycyclic aromatic hydrocarbon could result in various toxicities. This study evaluated the effects of long-term exposure to low doses of nickel and benzo [a] anthracene on the kidney of rats, simulating human exposure through food.

Methods: Thirty-six (36) Male rats weighing between 80-100 g were assigned into six groups of 6 animals each; Group A (normal), Group B1 and B2 (fed nickel contaminated feed for 12 and 24 weeks), Group C1 and C2 (fed benzo [a] anthracene contaminated feed for 12 and 24 weeks).

Heavy metal concentrations in four fish species from the Lagos lagoon and their human health implications.

Background: Lagos lagoon is constantly being polluted from industrial and human activities. Fishes from Lagos lagoon contribute significant percentages of fish consumption in the Lagos metropolises. Therefore, this study evaluated heavy metal concentrations in tissues of four fish species (, and ) from Lagos lagoons and their human health implication.

Ginger mitigated the health risks associated with arsenic-contamination of rats feed via inflammatory and apoptosis regulation.

Millions of people around the world are inadvertently exposed to arsenic through drinking water and food. However, food spices possess antioxidants and anti-inflammatory potentials. Therefore, this study evaluated the protective potentials of Zingiber officinale (ginger) against the toxic effects of arsenic in male Wistar rats.

Polycyclic aromatic hydrocarbons distribution in fish tissues and human health risk assessment on consumption of four fish species collected from Lagos Lagoon, Nigeria.

Lagos Lagoon is a very popular lagoon in Lagos state that receives effluents from neighboring industries. These effluents tend to increase the level of contaminants in the lagoon, thereby creating more stressors for aquatic animals. Determination of polycyclic aromatic hydrocarbons (PAHs) in four commonly consumed fish species from the lagoon and the prediction of possible health risks associated with their consumption were performed in this study.