Thyme () leaf extract modulates purinergic and cholinergic enzyme activities in the brain homogenate of 5-fluorouracil administered rats.

This study investigated the effect of Thyme () leaf aqueous extract (TE) on purine and acetylcholine hydrolyzing enzyme activities and antioxidant status in the brain of 5-fluorouracil (5-FLU) administered rats. Sixty adult Wistar rats (210-225 g) were divided into Ten groups ( = 6). Group 1: received normal saline orally (NC), group 2, 3, 4 and 5 rats were respectively received 100, 200 and 400 mg/kg of TE and Vitamin C (25 mg/kg) orally; group 6 rats received normal saline orally and 150 mg/kg of 5-FLU via .