Real-time visualization reveals Mycobacteriumtuberculosis ESAT-6 disrupts phagosome-like compartment via fibril-mediated vesiculation.

Mycobacterium tuberculosis (Mtb) evades host defense by hijacking and rupturing the phagosome. ESAT-6, a secreted virulence protein of Mtb, is known to be critical for phagosome rupture. However, the mechanism of ESAT-6-mediated disruption of the phagosomal membrane remains unknown.