Publications by authors named "Abiha Kazmi"
The development of multiomic profiling tools has rapidly expanded in recent years, along with their use in profiling skin tissues in various contexts, including dermatologic diseases. Among these tools, single-cell RNA-sequencing (scRNA-seq) and spatial transcriptomics (ST) have emerged as widely adopted and powerful assays for elucidating key cellular components and their spatial arrangement within skin disease. In this paper, we review the recent biological insights gained from the use of scRNA-seq and ST and the advantages of combining both for profiling skin diseases, including aberrant wound healing, inflammatory skin diseases, and cancer.
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- Activating mutations in PI3Kα are common in breast cancer and other tumors, with 12-15% of cases showing multiple mutations.
- The majority of these mutations are double mutations occurring on the same allele, leading to heightened PI3K activity and promoting tumor growth.
- Double mutations enhance sensitivity to PI3Kα inhibitors more than single mutations, due to mechanisms that disrupt inhibition and increase lipid binding.