Photodynamic therapy (PDT) is an effective and non-invasive treatment for actinic keratoses (AK) that has a variant called 'painless' PDT (p-PDT), which combines aminolevulinate incubation and blue light illumination.
A study involving 104 patients revealed that most experienced side effects, such as pain and erythema, 48 hours after p-PDT, with females reporting more intense symptoms compared to males.
The findings suggest that post-treatment inflammation is strongly linked to the severity of AK and may be necessary for the treatment's effectiveness.