Publications by authors named "Abigail Thacker"
Article Synopsis
- Growth/differentiation factors 5, 6, and 7 (GDF5/6/7) are key proteins involved in the early stages of bone and joint formation during embryonic development, with GDF5 being one of the first markers for joint formation.
- Mutations in the Gdf5 gene lead to specific skeletal defects, while mutations in Gdf6 result in different joint, ligament, and cartilage issues, revealing their unique roles in skeletal development.
- Mice lacking Gdf5 and Gdf6 display severe skeletal abnormalities, indicating that these factors are essential for normal bone and joint formation, and their disruptions may relate to some human skeletal disorders.
