Publications by authors named "Abigail Ray"
Article Synopsis
- * Researchers used genetic screening to identify key genes that help these persister cells survive during both normal and stress-induced conditions, uncovering a role for detoxifying reactive oxygen species (ROS).
- * They discovered that antibiotic exposure generates ROS, which can worsen bacterial death, and identified that the enzyme KatG is critical for the survival of persister cells under certain conditions, particularly in nutrient-deprived environments.
As a first line of host defense, macrophages must be able to effectively sense and respond to diverse types of pathogens, and while a particular type of immune response may be beneficial in some circumstances, it can be detrimental in others. Upon infecting a macrophage, () induces proinflammatory cytokines that activate antibacterial responses. Surprisingly, also triggers antiviral responses that actually hinder the ability of macrophages to control infection.
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