Impact of Anchor Location on Mitral Neochordae Forces: An In Vitro Study.

Purpose: This study examined changes in force distribution between the neochordae corresponding to different ventricular anchor locations.

Description: Seven porcine mitral valves were mounted in a left heart simulator. Neochordae (expanded polytetrafluoroethylene) originated from either a simulated left ventricular apex, papillary muscle base, or papillary muscle tip location.

Indirect evidence for a Ni-oxyl oxidant in the reaction of a Ni complex with peracid.

The reaction of a Ni complex and meta-chloroperoxybenzoic acid (m-CPBA) resulted in the formation of a long-lived Ni-chlorobenzoate complex that is a capable hydrocarbon oxidant. Analysis of the post-reaction decay products showed the formation of oxidised derivatives of the supporting ligand (a benzoxazine), and heterolytic O-O bond scission in m-CPBA. This evidence indicates formation of a more potent transient Ni-oxyl species, which was further supported by DFT calculations.