Sebaceous carcinoma of the right arm.

Sebaceous carcinoma is an uncommon cutaneous neoplasm that is often misdiagnosed as a benign lesion, but has an aggressive clinical behavior, including a rate of distant metastasis of up to 60%. In this paper, we describe a case of sebaceous carcinoma in the right arm of a 67-year-old woman. The relevant histopathology and appropriate diagnostic and treatment approach is discussed.

Phosphatidylinositol-3-kinase gamma plays a central role in blood-brain barrier dysfunction in acute experimental stroke.

Background And Purpose: Phosphoinositide 3-kinase (PI3K)-γ is linked to inflammation and oxidative stress. This study was conducted to investigate the role of the PI3Kγ in the blood-brain barrier dysfunction and brain damage induced by focal cerebral ischemia/reperfusion.

Methods: Wild-type and PI3Kγ knockout mice were subjected to middle cerebral artery occlusion (60 minutes) followed by reperfusion.

Isotope tracing enhancement of chemiluminescence assays for nitric oxide research.

Chemiluminescence assays are used widely for the detection of nitric oxide (NO)-derived species in biological fluids and tissues. Here, we demonstrate that these assays can be interfaced with mass-sensitive detectors for parallel determination of isotopic abundance. Results obtained with tri-iodide and ascorbic acid-based reductive assays indicate that mass spectrometric detection enables NO isotope-tracing experiments to be carried out to a limit of detectability of a few picomoles, a sensitivity similar to that of standard gas phase chemiluminescence methods.