Publications by authors named "Abigail O Ayodele"
Article Synopsis
- O-GlcNAcylation is a crucial nutrient-sensing process involving the proteins OGT and OGA, which add and remove O-GlcNAc modifications on proteins to maintain vital cellular functions.
- Research identified 159 clinically significant SNPs and specifically highlighted 7 mutations that likely have harmful effects on the OGT protein's function.
- Using molecular docking with the inhibitor OSMI-1, the study found strong binding interactions with the mutated proteins, suggesting these mutations could serve as potential drug targets for treating diabetes mellitus.
Prostate cancer is the second most common disease in men and the sixth leading cause of death from cancer globally, with 20 million men expected to be affected by 2024 thus considered as chronic illness which requires immediate attention. As an androgen-dependent illness that relies on the androgen receptor for development and progression, inhibition of the androgen receptor can lead to a therapeutic solution, hence serving as a vital therapeutic target. This study focused on the computational analysis of the inhibitory potentials of Vitis vinifera, a reported plant with anti-cancer properties, against androgen receptor employing molecular docking, ADMET studies, Binding energy study, pharmacophore modeling, and molecular dynamics simulation approaches.
View Article and Find Full Text PDF