Introduction: Investigations into consequences of the US COVID-19 pandemic for older adults with dementia have been limited.
Methods: We used the National Health and Aging Trends Study to examine self-reported COVID-19 infection; measures taken to limit its spread; social, behavioral, and emotional responses to the pandemic; and changes in health-care use and provider communication. We compared adults aged ≥70 with and without dementia in community and residential care settings.
We recently found that dual decline in memory and gait speed was consistently associated with an increased risk of dementia compared to decline in memory or gait only or no decline across six aging cohorts. The mechanisms underlying this relationship are unknown. We hypothesize that individuals who experience dual decline may have specific pathophysiological pathways to dementia which can be indicated by specific metabolomic signatures.
View Article and Find Full Text PDFBackground: Being physically active has multiple salutary effects on human health, likely mediated by changes in energy metabolism. Recent reviews have summarized metabolomic responses to acute exercise. However, metabolomic profiles of individuals who exercise regularly are heterogeneous.
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