Publications by authors named "Abigail Carranza"
Article Synopsis
- Robo3 is part of the Roundabout receptor family and plays a unique role in axon pathway formation during embryonic development, differing from typical Slit-dependent mechanisms.
- Researchers developed various Robo3 variants to understand the function of the N-terminal Ig1 domain and its interaction with Slit.
- The study finds that while Robo3's Ig1 domain is essential for Slit binding and neuronal localization, it can still guide axons independently of Slit, suggesting additional sequences contribute to its guidance capabilities.
