Publications by authors named "Abigail Browne"
Article Synopsis
- Disordered sleep and musculoskeletal pain often occur together, and interventions like Cognitive Behavioural Therapy for Insomnia (CBT-I) are investigated for their effectiveness in treating both conditions simultaneously.
- A review of 12 studies showed that CBT-I typically includes core elements such as sleep restriction and stimulus control, along with additional methods like sleep education and relaxation strategies, maintaining a consistent weekly schedule over 5-9 weeks.
- While there was a general agreement on the components and frequency of CBT-I sessions in the studies, there was some lack of clarity in reporting specific details, such as who delivered the interventions and the exact content covered in the sessions.
This study investigated the oral bioavailability and efficacy of BILS 45 BS, a selective herpes simplex virus (HSV) helicase-primase inhibitor, against acyclovir (ACV)-resistant (ACV(r)) infections mediated by the HSV type 1 (HSV-1) dlsptk and PAA(r)5 mutant strains. In vitro, the compound was more potent than ACV against wild-type clinical and laboratory HSV-1 strains and ACV(r) HSV isolates, as determined by a standard plaque reduction assay, with a mean 50% effective concentration of about 0.15 microM.
View Article and Find Full Text PDF