JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician.

Guidelines for primary care clinicians on monitoring and safety guidelines regarding Janus kinase and tyrosine kinase 2 inhibitors in the treatment of inflammatory skin conditions are often unclear. This review aims to provide the primary care physician with a review of clinically relevant and updated information regarding the monitoring and overall profile of these medications. To do so, a systematic review was conducted using the PubMed database and relevant Food and Drug Administration (FDA) approved drug inserts from manufacturers.

Ossifying Panniculitis Presenting as a Painful Nodule on the Abdomen.

Myositis ossificans is a benign ossifying nodule that can affect any type of tissue but is most commonly found in muscle. Occurrence in the soft tissue of the subcutis is less common and has been referred to as panniculitis ossificans. In this case report, we describe a 46-year-old woman who presented with a 1.

Synergy between formal and informal education.

The informal components of education can shape a person's capacity to contribute. Such informal components might include cultural backgrounds, work experiences, and extracurricular pursuits. To appreciate the synergy between formal and informal education it can be helpful to explore a particular case of someone who actually combined the two to make the whole more than the sum of its parts.

Short-term exposure to unmanned aerial vehicles does not alter stress responses in breeding tree swallows.

Recent studies suggest that visual and acoustic anthropogenic disturbances can cause physiological stress in animals. Human-induced stress may be particularly problematic for birds as new technologies, such as drones, increasingly invade their low-altitude air space. Although professional and recreational drone usage is increasing rapidly, there is little information on how drones affect avian behavior and physiology.

The lncRNA BORG facilitates the survival and chemoresistance of triple-negative breast cancers.

Disseminated breast cancer cells employ adaptive molecular responses following cytotoxic therapeutic insult which promotes their survival and subsequent outgrowth. Here we demonstrate that expression of the pro-metastatic lncRNA BORG (BMP/OP-Responsive Gene) is greatly induced within triple-negative breast cancer (TNBC) cells subjected to environmental and chemotherapeutic stresses commonly faced by TNBC cells throughout the metastatic cascade. This stress-mediated induction of BORG expression fosters the survival of TNBC cells and renders them resistant to the cytotoxic effects of doxorubicin both in vitro and in vivo.