Publications by authors named "Abigail B Abrahams"
Unlabelled: Peptide-based treatments represent an expanding area and require innovative approaches to enhance bioavailability. Combination with cell-penetrating peptides (CPPs) is an attractive strategy to improve non-invasive delivery across nasal epithelial barriers for systemic and direct nose-to-brain transport. We previously developed a modified CPP system termed Glycosaminoglycan-binding Enhanced Transduction (GET) that improves insulin delivery across gastrointestinal epithelium.
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- A study in the UK found that 13-55% of patients with depression don’t respond well to antidepressants, meaning they still feel sad despite taking medication.
- Out of 184 patients who started treatment, 47% still had depression symptoms after 48 weeks, and 20% were classified as having a consistent lack of response to treatment.
- Most patients didn't visit their doctors during the study, which suggests that doctors need to find better ways to track patients' progress and help those who aren’t getting better.