[Technogenic factors of ecological impact on properties of snake venom].

In article comparative literary and experimental data about degree of a level of scrutiny of snake venoms are presented. Obtained data shows that increased pollution of industrial regions results in higher levels of heavy metals in snake venom. Change of physical and chemical parametres, and also pharmacological activity and toxicity of zootoxins under influence biotics, abiotics factors and including heavy metals and radiation is noted.

[Influence of electromagnetic radiation on toxicity of Vipera lebetina obtusa venom].

The aim of the article was to study the effect of electromagnetic radiation on toxicity of Vipera lebetina obtusa venom. It was found that mice intoxicated with snake venom, with moderate to high exposure to electromagnetic radiation and mice intoxicated with venom, which had not been exposed to the radiation showed the same symptoms of intoxication and death. At the same time, the longevity of mice intoxicated with venom exposed to electromagnetic radiation was higher.

[Atom-absorption spectrometry in studying of Vipera lebetina obtusa venom].

The aim of the investigation was to work out the atom-absorption spectrometry method for definition of elementary structure of snake venom. The investigation was conducted on venom vipers, caught in the Gobustan district. Determination of heavy metals in venom vipers, was conducted by means of atom-absorption spectrometry (Perkin-Elmer AAS-300).

[Alpha-tocopherol inhibition of erythema in skin photosensitized by 8-methoxypsoralen].

Irradiation of the rabbit and human skin by near UV light (wave lengths greater than 320 nm) in the presence of 8-methoxypsoralen produced erythema, pigmentation and some changes in the mechanical and electric properties. All the photobiological effects mentioned were inhibited by alpha-tocopherol if it was applied before irradiation. When applied after exposure to irradiation alpha-tocopherol appeared to be ineffective.

[Mechanism of the photochemical reaction between 8-methoxypsoralen and DNA: formation of fluorescent cycloadducts].

Irradiation of double-stranded DNA solutions containing 8-methoxypsoralene /8-MOP/ by near ultraviolet light /365 nm/ resulted in the formation of fluorescent photoaddiucts 8-MOP-DNA. The fluorescence of these products in the DNA molecule is considerably quenched due to the intercalation between the bases. After hydrolysis of DNA the quenching was eliminated.