Publications by authors named "Abiba Doukani"

Recently, an intestinal dysbiotic microbiota with enrichment in oral cavity bacteria has been described in colorectal cancer (CRC) patients. Here, we characterize and investigate one of these oral pathobionts, the Gram-positive anaerobic coccus . We identified two phylotypes (A and B) exhibiting different phenotypes and adhesion capabilities.

View Article and Find Full Text PDF

Aims: The distinction between CNS WHO grade 2 and grade 3 is instrumental in choosing between observational follow-up and adjuvant treatment for resected astrocytomas IDH-mutant. However, the criteria of CNS WHO grade 2 vs 3 have not been updated since the pre-IDH era.

Methods: Maximal mitotic activity in consecutive high-power fields corresponding to 3 mm was examined for 118 lower-grade astrocytomas IDH-mutant.

View Article and Find Full Text PDF

Early life periconceptional exposures during assisted reproductive technology (ART) procedures could alter the DNA methylation profiles of ART children, notably in imprinted genes and repetitive elements. At the genome scale, DNA methylation differences have been reported in ART conceptions at birth, but it is still unclear if those differences remain at childhood. Here, we performed an epigenome-wide DNA methylation association study using Illumina InfiniumEPIC BeadChip to assess the effects of the mode of conception on the methylome of buccal cells from 7- to 8-year-old children (48 children conceived after ART or naturally (control, CTL)) and according to the embryo culture medium in which they were conceived.

View Article and Find Full Text PDF
Article Synopsis
  • Biopharmaceutical products, often used to treat autoimmune diseases, face challenges with immunogenicity and the development of antidrug antibodies (ADAs), impacting treatment efficacy for many patients.
  • A study by the European consortium ABIRISK analyzed 560 patients with multiple sclerosis, rheumatoid arthritis, and inflammatory bowel diseases over a year to explore patient-related factors that influence ADA development.
  • The findings revealed that immunosuppressants and antibiotics negatively correlated with ADA development time, while infections and tobacco smoking positively correlated with an increased risk of developing ADAs.
View Article and Find Full Text PDF