Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population.

Background: Angiotensinogen (AGT) enzyme comprises a vital module of RAAS system that effectively controls the blood pressure and related cardiovascular functions. Ample association studies have reported the importance of AGT variants in cardiovascular and non-cardiovascular adversities. But lately, owing to the complexity of the many anomalies, the haplotype based examination of genetic variation that facilitates the identification of polymorphic sites which are located in the vicinity of the causative polymorphic site, gets greater appreciation.

Menarcheal age of type 1 diabetic Bengali Indian females.

Background: It has been observed that menstrual characteristics are generally influenced by lifestyle, socio-cultural and biological factors.

Aim: The present study examines: (a) variation in menstrual characteristics between Type1 Diabetic females of rural and urban adolescents, i.e.

Absence of p53 gene mutations in exons 5 - 7 among breast cancer patients of Bengalee Hindu caste females, West Bengal, India.

Background: The high incidence and relatively good prognosis of breast cancer has made it the most prevalent cancer in the world today. A large number of distinct mutations and polymorphisms in the p53 gene have been reported worldwide, but there is no report regarding the role of this inherited susceptibility gene in breast cancer risk among the Bengalee Hindu Caste females of West Bengal, India.

Aim Of The Study: We investigated the distribution and the nature of p53 gene mutations and polymorphisms in exons 5-7 in a cohort of 110 Bengalee Hindu breast cancer patients and 127 age, sex and caste matched controls by direct sequencing.

Menstrual characteristics: a study of the adolescents of rural and urban West Bengal, India.

Background: It has been observed that menstrual characteristics are generally influenced by lifestyle, socio-cultural and biological factors.

Aim: The present study examines: (a) variation in menstrual characteristics between rural and urban adolescents; and (b) whether these characteristics can be predicted from various socio-economic variables related to place of residence.

Subjects And Methods: The sample of the present study constituted 715 adolescent girls from rural (325) and urban (390) areas of West Bengal, a State of India.