Publications by authors named "Abhishek Ranga"
Role of miRNAs in breast cancer development and progression: Current research.
Biofactors
December 2024
Breast cancer, a complex and heterogeneous ailment impacting numerous women worldwide, persists as a prominent cause of cancer-related fatalities. MicroRNAs (miRNAs), small non-coding RNAs, have garnered significant attention for their involvement in breast cancer's progression. These molecules post-transcriptionally regulate gene expression, influencing crucial cellular processes including proliferation, differentiation, and apoptosis.
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- Hepatitis B virus (HBV) is a complex blood-borne virus that causes chronic hepatitis B and has a diverse genetic makeup, making treatment challenging.
- The HBV polymerase is crucial for the virus's replication and has been identified as a target for new drugs, but existing treatments have limitations, such as developing resistance and high costs for patients.
- The study reviews various classes of inhibitors that target different parts of the HBV polymerase, examines host factors involved in HBV replication, and analyzes the chemistry of these inhibitors to aid in creating more effective treatments.