Publications by authors named "Abhishek Payal"
Vitamin D Supplementation and Remission from Chronic Anterior Uveitis.
Ocul Immunol Inflamm
November 2024
Purpose: Chronic anterior uveitis (CAU) often requires suppressive therapy, which has potential side effects including cataract, ocular hypertension, and increased risk of infection. No remittive therapy is currently available; however, several studies have demonstrated an association between low 25-hydroxy Vitamin D (25OHD) levels and either uveitis incidence or uveitis disease activity. This study investigates the potential of Vitamin D supplementation as a remittive treatment for CAU.
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- A study evaluated the incidence of significant posterior capsule opacification (PCO) and YAG laser capsulotomy among uveitic eyes after cataract surgery, revealing that about 16% of eyes experienced PCO with reduced visual acuity within a year.* -
- Analysis of 1,855 uveitic eyes found that younger patients, those with poorer preoperative vision, and postoperative inflammation were more likely to develop PCO, while younger age and female sex were risk factors for needing YAG laser capsulotomy.* -
- The findings indicate that PCO is common in uveitic patients post-surgery, with 22% of eyes undergoing YAG laser treatment in the same timeframe, emphasizing the need for
Article Synopsis
- The study aimed to analyze the relationship between immunosuppression and overall as well as cancer-specific mortality in patients with noninfectious ocular inflammatory disease.
- Researchers examined data from over 15,000 patients over a median of 10 years and found there were 1970 deaths, with 435 attributed to cancer.
- The results indicated that patients on various immunosuppressants experienced similar mortality rates compared to the general U.S. population, suggesting that these treatments did not significantly increase overall or cancer mortality risk.
Article Synopsis
- The study aimed to estimate the incidence of corneal endothelial transplantation (CET) and identify risk factors in patients with noninfectious ocular inflammation using data from a cohort study of adult patients in the U.S.
- A total of 14,264 eyes were analyzed, revealing a 10-year incidence rate of 1.10% for CET, with notable risk factors including older age (over 60), specific types of inflammation (anterior uveitis and scleritis), and prior operations like cataract and tube shunt surgery.
- The findings suggest that while CET is rare among these patients, certain conditions like hypotony and band keratopathy significantly increase the likelihood of requiring the procedure.
Purpose: To determine the incidence of and predictive factors for cataract in intermediate uveitis.
Design: Retrospective cohort study.
Methods: Patients were identified from the Systemic Immunosuppressive Therapy for Eye Diseases Cohort Study, in which medical records were reviewed to determine demographic and clinical data of every eye/patient at every visit at 5 participating US tertiary care uveitis centers.
Purpose: To determine the efficacy and safety of infliximab therapy in patients with HLA B-27-associated ocular inflammation resistant or intolerant to conventional immunomodulatory therapy.
Methods: This was a retrospective observational case series. All cases were uveitic patients with positive HLA-B27, confirmed through HLA testing, resistant or intolerant to conventional immunomodulatory therapy.
Purpose: To assess how often non-infectious anterior scleritis remits and identify predictive factors.
Methods: Our retrospective cohort study at four ocular inflammation subspecialty centers collected data for each affected eye/patient at every visit from center inception (1978, 1978, 1984, 2005) until 2010. Remission was defined as inactivity of disease off all suppressive medications at all visits spanning at least three consecutive months or at all visits up to the last visit (to avoid censoring patients stopping follow-up after remission).
Healthy Worker Effect Phenomenon: Revisited with Emphasis on Statistical Methods - A Review.
Indian J Occup Environ Med
January 2017
Known since 1885 but studied systematically only in the past four decades, the healthy worker effect (HWE) is a special form of selection bias common to occupational cohort studies. The phenomenon has been under debate for many years with respect to its impact, conceptual approach (confounding, selection bias, or both), and ways to resolve or account for its effect. The effect is not uniform across age groups, gender, race, and types of occupations and nor is it constant over time.
View Article and Find Full Text PDFPurpose: To compare training effect of 2 training models-a surgical simulator anti-tremor module and a paper version-on tremor and time-to-task completion.
Setting: Ophthalmology Department, Veterans Affairs Boston Healthcare System, Jamaica Plain, Massachusetts, USA.
Design: Prospective crossover study.
Objective: To compare clinical outcomes of cataract surgery in eyes with and without pseudoexfoliation (PXF).
Design: Retrospective deidentified data analysis.
Participants: A total of 123 PXF and 4776 non-PXF eyes of patients who underwent cataract surgery.
Purpose: To evaluate construct and face validity of the Eyesi Binocular Indirect Ophthalmoscope Simulator.
Methods: The performance of 25 medical students (Group A) was compared with that of 17 ophthalmology and optometry trainees (Group B) on the Eyesi Binocular Indirect Ophthalmoscope Simulator. During the course of a single session, each participant viewed an orientation module followed by an instruction session and a demonstration case, and performed 6 cases of progressively increasing difficulty (4 levels) and a 10-question face validity questionnaire.
Purpose: To explore the association of American Society of Anesthesiologists (ASA) classification with cataract surgery outcomes.
Setting: Five Veterans Affairs Medical Centers, United States.
Design: Retrospective observational cohort study.
Purpose: To evaluate the outcomes of the Ex-PRESS Filtration Device in patients with uveitic glaucoma.
Methods: We reviewed 23 eyes, comparing control simple glaucoma patients (n = 11) to uveitic glaucoma patients (n = 12). Intraocular pressure (IOP) and glaucoma medications at the preoperative examination were compared with those at the 6-month and 10-14-month postoperative examination.
Purpose: To explore visual outcomes, functional visual improvement, and events in resident-operated cataract surgery cases.
Setting: Veterans Affairs Ophthalmic Surgery Outcomes Database Project across 5 Veterans Affairs Medical Centers.
Design: Retrospective data analysis of deidentified data.
Purpose: To determine whether a structured training program using the validated EYESI surgical simulator improves dexterity in nondominant (ND) hands.
Setting: Academic tertiary referral center.
Design: Nonrandomized, prospective study.
Chemical agents that target the eyes have been a popular choice for law enforcement during riots and for military training for nearly a century. The most commonly used agents are chloroacetophenone (formerly sold as Mace), o-chlorobenzylidene malononitrile, and oleoresin capsicum (OC or pepper spray, current ingredient for Mace). Initially, most severe ocular injuries were caused by the explosive force rather than the chemical itself.
View Article and Find Full Text PDFLong-Term Drug-Free Remission and Visual Outcomes in Sympathetic Ophthalmia.
Ocul Immunol Inflamm
April 2017
Purpose: To assess corticosteroid- and immunosuppressive therapy (IST)-free long-term remission in the treatment of patients with sympathetic ophthalmia (SO), a vision-robbing disease that can span a lifetime.
Methods: The medical records of 19 patients with SO aged 16.1 to 94.
Purpose: To evaluate the incidence of remission among patients with intermediate uveitis; to identify factors potentially predictive of remission.
Design: Retrospective cohort study.
Methods: Involved eyes of patients with primary noninfectious intermediate uveitis at 4 academic ocular inflammation subspecialty practices, followed sufficiently long to meet the remission outcome definition, were studied retrospectively by standardized chart review data.
Purpose: To compare visual acuity outcomes, vision-related quality of life, and complications related to cataract surgery in eyes with and without glaucoma.
Design: Retrospective cohort study.
Methods: Cataract surgery outcomes in cases with and without glaucoma from the Veterans Affairs Ophthalmic Surgical Outcomes Data Project were compared.
Purpose: To evaluate outcomes of long-term follow-up of Retisert multiple implantation and dissociation in eyes with chronic noninfectious uveitis.
Methods: Review of 187 consecutive Retisert implants. Outcomes of multiple implantation and spontaneous medication pellet-strut dissociation were evaluated.
Purpose: To evaluate the reliability of clinical grading of vitreous haze using a new 9-step ordinal scale versus the existing 6-step ordinal scale.
Design: Evaluation of diagnostic test (interobserver agreement study).
Participants: A total of 119 consecutive patients (204 uveitic eyes) presenting for uveitis subspecialty care on the study day at 1 of 3 large uveitis centers.
Purpose: To report the outcomes of infliximab treatment of birdshot retinochoroidopathy (BSRC) refractory to conventional immunomodulatory therapy.
Design: Retrospective case series.
Participants: Twenty-two refractory birdshot retinochoroidopathy patients (44 eyes) who received infliximab between July 2005 and June 2012 were identified by retrospective chart review.
Purpose Of Review: To review the previous year's literature related to prevalence of blindness in general, blindness due to cataract, cataract surgical coverage (CSC) and cataract surgical rates (CSRs).
Recent Findings: Cataracts are the major cause of blindness and visual impairment in developing countries and contributes to more than 90% of the total disability adjusted life years. This review shows that coverage continues to be a problem in many countries, especially for the female population, those residing in rural areas and those who are illiterate.