Newborn Screening for Sickle Cell Disease Among Tribal Populations in the States of Gujarat and Madhya Pradesh in India: Evaluation and Outcome Over 6 Years.

Sickle cell disease (SCD) poses considerable public health problems in India. This study was undertaken to understand the clinical course of SCD among children identified during newborn screening programmes in Gujarat and Madhya Pradesh where the frequency of the HbS gene is high. A total of 8,916 newborn babies 8,411 from Gujarat and 505 from Madhya Pradesh were screened over 6 years (2010-2016) using HPLC and the diagnosis was confirmed by molecular analysis in a subset.

Effect of Combined Therapy Using Diode Laser and Photodynamic Therapy on Levels of IL-17 in Gingival Crevicular Fluid in Patients With Chronic Periodontitis.

The aim of this study was to evaluate the efficacy of combination therapy of diode laser and photodynamic therapy (PDT) as an adjunct to scaling and root planing (SRP) on interleukin-17 (IL-17) levels in gingival crevicular fluid (GCF) in patients with chronic periodontitis. Thirty subjects with chronic periodontitis were included. All teeth received periodontal treatment comprising of SRP.

Transfusion in sickle cell disease: experience from a Gujarat centre.

Objectives: Following impressions that the use of blood transfusion in sickle cell disease may be inappropriately high, transfusion practice at a major blood bank in an area of high prevalence of sickle cell disease was assessed.

Methods: Retrospective review of blood usage in sickle cell disease at a major blood bank in south Gujarat in 2010 was conducted with prospective more detailed data collection over 18 wk period (April 7 through August 15) in 2011. The results were compared with transfusion usage in the Jamaican Sickle Cell Clinic.