Mechanisms and early efficacy data of caloric restriction and caloric restriction mimetics in neurodegenerative disease.

Neurodegenerative disorders (NDDs) have been prevalent for more than a decade, and the number of individuals affected per year has increased exponentially. Among these NDDs, Alzheimer's disease, which causes extreme cognitive impairment, and Parkinson's disease, characterized by impairments in motor activity, are the most prevalent. While few treatments are available for clinical practice, they have minimal effects on reversing the neurodegeneration associated with these debilitating diseases.

TiCT MXene Functionalized via Boron Doped MoS Quantum Dots: A Synergy of Heterojunctions and Doping Effect Enabling Ultrasensitive SO Detection at Room Temperature.

The design of mixed-dimensional heterostructures has emerged to be a new frontier of research as it induces exciting physical/chemical properties that extend beyond the fundamental properties of single dimensional systems. Therefore, rational design of heterostructured materials with novel surface chemistry and tailored interfacial properties appears to be very promising for the devices such as the gas sensors. Here, a highly sensitive gas sensor device is constructed by employing heterostructures of boron doped molybdenum disulfide quantum dots (B-MoS Qdots) assembled into the matrix of TiCT MXene.

Gut-brain axis and brain health: modulating neuroinflammation, cognitive decline, and neurodegeneration.

The microbiota-gut-brain axis is a pivotal medium of crosstalk between the central nervous system (CNS) and the gastrointestinal tract. It is an intricate network of synergistic molecular pathways that exert their effects far beyond their local vicinity and even affect the systemic functioning of the body. The current review explores the involvement of the gut-brain axis (GBA) in the functioning of the nervous system, with a special emphasis on the neurodegeneration, cognitive decline, and neuroinflammation that occur in Alzheimer's disease (AD) and Parkinson's disease (PD).

Self-Assembly of a Perfluorinated Amphiphilic Cyanine Dye into Branched Tubular J-Aggregates.

The self-assembly process is governed by the individual constituents of molecules through precise non-covalent interactions. Amphiphilic cyanines are intriguing in supramolecular chemistry due to the large polarizability of their delocalized π-electron systems, their tuneable optical properties and their ability to form well-defined self-assembled structures in different media. Here we present the synthesis of a novel tetrahydroxy amphiphilic carbocyanine dye with perfluoro alkylated chains -(CH)-(CF)-CF as hydrophobic segments and aminoproanediol as hydrophilic segment.

Assessment of feeding hydroponic fodder on growth and reproduction performance in Black Bengal goat.

This study aimed to evaluate the effects of hydroponic fodder on the growth and reproductive performance of Black Bengal goats in East Champaran, Bihar, during the years 2020-21 and 2021-22. A total of 24 goats were randomly assigned to four groups: Control (C) with extensive grazing, gram straw, concentrate feed, and green fodder; Treatment 1 (T1) receiving C + 300 g/day of wheat hydroponic fodder; Treatment 2 (T2) with 300 g/day of maize hydroponic fodder alone; and Treatment 3 (T3) receiving C + a combination of 150 g/day of wheat and 150 g/day of maize hydroponic fodder. Each group comprised 6 animals.

Particulate matter exposure and its consequences on hippocampal neurogenesis and cognitive function in experimental models.

Exposure to air pollution is thought to cause millions of deaths globally each year. According to the Who 2018, approximately 7 million deaths annually are caused predominantly by noncommunicable diseases due to air pollution. Exposure to air particulate matter 2.

Protective Effects of Chlorogenic Acid Against Amyloid-Beta-Induced Oxidative Stress and Ion Transport Dysfunction in SH-SY5Y Cells.

Caloric restriction mimetics mimic the beneficial effects of dietary restriction approaches, such as caloric restriction approaches, without limiting the dietary intake. Chlorogenic acid (CGA) acts as a caloric restriction mimetic; however, its neuroprotective mechanisms remain ambiguous. Therefore, in this study, we aimed to elucidate the neuroprotective effects of CGA on SH-SY5Y cells treated with amyloid-beta (Aβ)1-42.

Spermidine protects cellular redox status and ionic homeostasis in D-galactose induced senescence and natural aging rat models.

Impaired redox homeostasis is an important hallmark of aging. Among various anti-aging interventions, caloric restriction mimetics (CRMs) are the most effective in promoting health and longevity. The potential role of spermidine (SPD) as a CRM in modulating oxidative stress and redox homeostasis during aging remains unclear.

Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration.

Aging, an inevitable physiological process leading to a progressive decline in bodily functions, has been an abundantly researched domain with studies attempting to slow it down and reduce its debilitating effects. Investigations into the cellular and molecular pathways associated with aging have allowed the formulation of therapeutic strategies. Of these, caloric restriction (CR) has been implicated for its role in promoting healthy aging by modulating key molecular targets like Insulin/IGF-1, mTOR, and sirtuins.

Valley-Polarized Topological Phases with In-Plane Magnetization.

The coexistence of valley polarization and topology has considerably facilitated the applications of 2D materials toward valleytronics device technology. However, isolated and distinct valleys are required to observe the valley-related quantum phenomenon. Herein, we report a new mechanism to generate in-plane magnetization direction-dependent isolated valley carriers by preserving or breaking the mirror symmetry in a 2D system.

Comparative toxicity assessment of selected nanoparticles using different experimental model organisms.

Nanoparticles are microscopic particles ranging in size from one to one hundred nanometers. Due to their extensive features, nanoparticles find widespread use in various fields worldwide, including cosmetics, medical diagnosis, pharmaceuticals, food products, drug delivery, electronic devices, artificial implants, and skincare. However, their unique characteristics have led to high demand and large-scale manufacturing, resulting in adverse impacts on the environment and bioaccumulation.

Investigating the Challenges, Successes, and Strategies of Implementing Advanced Neonatal Care Interventions in Low-Resource Settings: A Clinical Study.

Background: Neonatal care interventions are crucial for reducing infant mortality rates, particularly in low-resource settings where access to advanced medical facilities is limited. Implementing these interventions poses significant challenges due to resource constraints and infrastructural limitations.

Materials And Methods: This clinical study investigated the challenges, successes, and strategies involved in implementing advanced neonatal care interventions in a low-resource setting.

Assessing Practices and Challenges in Providing Nutritional Support to Neonates and Children Pre- and Post-Surgery, and its Impact on Recovery and Outcomes.

Background: Providing adequate nutritional support to neonates and children undergoing surgery is crucial for their recovery and overall health outcomes. However, there are various challenges associated with this, including the unique nutritional requirements of this population and the potential complications that can arise pre- and post-surgery.

Materials And Methods: This study aimed to assess the practices and challenges in providing nutritional support to neonates and children both pre- and post-surgery, and to analyze its impact on recovery and outcomes.

Adoption, Outcomes, and Healthcare Professionals' Perceptions of Minimally Invasive Surgical Techniques in Neonatology and Pediatric Surgery: A Clinical Study.

Background: Minimally invasive surgical techniques have revolutionized neonatology and pediatric surgery by offering less traumatic procedures with reduced recovery times and improved outcomes. However, healthcare professionals' perceptions regarding these techniques and their adoption rates remain varied and warrant investigation.

Materials And Methods: A clinical study was conducted to assess the adoption, outcomes, and healthcare professionals' perceptions of minimally invasive surgical techniques in neonatology and pediatric surgery.

New Insights into the Diagnosis, Monitoring, and Management of Antenatal Hydronephrosis, Aiming to Refine Treatment Protocols: A Clinical Study.

Background: Antenatal hydronephrosis (ANH) is a common prenatal finding that requires careful evaluation to determine appropriate management strategies. The variability in outcomes underscores the need for refined diagnostic and monitoring protocols to differentiate between cases necessitating intervention and those likely to resolve spontaneously.

Materials And Methods: A prospective clinical study was conducted involving 150 pregnant women diagnosed with ANH between gestational weeks 18 to 24.

Development and characterization of sodium alginate and β-cyclodextrin nanoemulsions encapsulating betel leaf (Piper betle L.) extract for enhanced antimicrobial efficacy against foodborne pathogen.

This study aims to investigate the physical stability, droplet size, zeta potential, and antimicrobial properties of nanoemulsions formulated with betel leaf extract using β-cyclodextrin (CD) and sodium alginate (SA) biopolymers. Nanoemulsions with β-cyclodextrin exhibit superior stability at lower temperatures, with limited droplet size, and strong electrostatic repulsion. Morphological images demonstrate the successful encapsulation of betel leaf extract within both biopolymers, highlighting their potential for antimicrobial applications.

Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders.

The gut microbiota (GM) produces various molecules that regulate the physiological functionality of the brain through the gut-brain axis (GBA). Studies suggest that alteration in GBA may lead to the onset and progression of various neurological dysfunctions. Moreover, aging is one of the prominent causes that contribute to the alteration of GBA.

Fabrication and characterization of SbO-MoSnanocomposites for high performance supercapacitor applications.

Binary nanocomposite-based electrodes have been studied extensively in recent times owing to their multiple oxidation states, excellent physico-chemical features, and combined morphology, which are suitable for increasing the electrochemical performance of supercapacitors. The present work deals with SbO-MoSnanocomposites electrode for supercapacitor applications. The x-ray diffraction (XRD), Raman, scanning electron microscope (SEM), energy dispersive x-ray (EDX), high-resolution transmission electron microscopy (HRTEM), selected area electron diffraction (SAED) and x-ray photoelectron spectroscopy (XPS) characterizations have been studied to analyze the phase formation, vibrational modes, morphology, elemental composition and binding energies of the prepared SbO-MoSnanocomposites electrode material, as well as their electrochemical measurements such as cyclic voltammetry (CV), galvanostatic charge-discharge (GCD), and electrochemical impedance spectroscopy (EIS) have been analyzed.

Non-Debye to Debye spectral shift in solid solutions of orientationally disordered crystals.

Debye relaxation is a simple and unique physical mechanism by which a macroscopic orientational polarization decays monoexponentially with time. However, the very existence of the Debye process in complex systems such as water, aqueous solutions, and monohydroxyl alcohols, among others, is puzzling to date and their microscopic origin is still ambiguously explained. In order to shed light on some of these aspects, orientational dynamics of an orientationally disordered dipolar crystal with an identically structured nonpolar matrix has been studied in the form of solid solutions.