Fabricating gum polysaccharides based nano-composites for drug delivery uses via sustainable green approach.

Recent advancements in development of natural polymer nono-composites led to exploration of potential of gum acacia (GA) and tragacanth gum (TG) for design of silver nanoparticles (AgNPs) impregnated grafted copolymers via green approach for use in drug delivery (DD). The formation of copolymers was confirmed by UV-Vis spectroscopy, TEM, SEM, AFM, XPS, XRD, FTIR,TGA and DSC. UV-Vis spectra indicated the formation of AgNPs using GA as reducing agent.

Nasal Polyposis and Its Association with Cardiac Functions.

Objective: The aim of the study was to ascertain the effect of nasal polyposis on cardiac functions.

Material And Methods: A prospective randomized interventional open-label endpoint-controlled study was conducted in an academic tertiary care hospital. Thirty-one patients with chronic rhinosinusitis with nasal polyposis were enrolled and administered fluticasone furoate nasal spray for 3 weeks before randomly segregation into surgical or medical group.

Acacia gum polysaccharide based hydrogel wound dressings: Synthesis, characterization, drug delivery and biomedical properties.

Keeping in view the importance of polysaccharide gums for wound care, in the present article, an attempt has been made to explore antioxidant nature of gum acacia in designing hydrogel wound dressing to improve its wound healing potential. These polymers were prepared by using acacia gum-polyvinylpyrollidone/carbopol and were characterized by C NMR, FTIR, SEM, AFM, cryo-SEM, XRD, TGA, DSC and elemental analysis techniques. Some important biomaterial properties of wound dressings such as wound fluid absorption, haemo-compatibility, bioactive assessment, gaseous/water/microbial permeability, mechanical properties, bio-adhesion, drug release, and histology of wound healing were also determined.

Evaluation of Gentamicin and Lidocaine Release Profile from Gum Acacia-crosslinked-poly(2-hydroxyethylmethacrylate)-carbopol Based Hydrogels.

Background: No doubt, the prevention of infection is an indispensable aspect of the wound management, but, simultaneous wound pain relief is also required. Therefore, herein this article, incorporation of antibiotic agent 'gentamicin' and pain relieving agent 'lidocaine' into hydrogel wound dressings, prepared by using acacia gum, carbopol and poly(2-hydroxyethylmethacrylate) polymers, has been carried out. The hydrogels were evaluated as a drug carrier for model drugs gentamicin and lidocaine.

Slow release of ciprofloxacin from β- cyclodextrin containing drug delivery system through network formation and supramolecular interactions.

Supramolecular cyclodextrin (CD) hydrogels have occupied an important position in developing the materials for biomedical application. In the present work an attempt has been made to improve the release profile of ciprofloxacin by designing the β- cyclodextrin containing drug delivery system through network formation and supramolecular interactions. The polymer network has been formed by sterculia gum comprising of glucuronic acid and galacturonic acid and carbopol.

Design of antibiotic containing hydrogel wound dressings: biomedical properties and histological study of wound healing.

Keeping in view the antioxidant nature of the acacia gum and mucoadhesive nature of carbopol hydrogels, in the present studies, an attempt has been made to explore the potential of these materials in designing new hydrogel wound dressings meant for slow release of gentamicin, an antibiotic drug, and to enhance the wound healing potential. The hydrogel films were characterized by SEM, FTIR, XRD and swelling studies. Biomedical properties of hydrogel films like blood compatibility, antioxidant activity, mucoadhesion, antimicrobial activity, oxygen/water vapour permeability, microbial penetration and mechanical properties (tensile strength, burst strength, resilience, relaxation, and folding endurance) have been evaluated.