Design and Synthesis of Zn -Coordination Polymers Anchored with NSAIDs: Metallovesicle Formation and Multi-drug Delivery.

A series of coordination polymers synthesized from a bis-pyridyl linker, namely 4,4'-azopyridine (L), selected non-steroidal-anti-inflammatory drugs (NSAIDs), namely diclofenac (Dic), ibuprofen (Ibu), flurbiprofen (Flu), mefenamic acid (Mefe), and naproxen (Nap), and Zn(NO ) were characterized by single crystal X-ray diffraction. One of the coordination polymers, namely CP3 derived from Flu, was able to form metallovesicles in DMSO, DMSO/H O and DMSO/DMEM (biological media) as revealed by TEM, AFM and DLS. Metallovesicle formation by CP3 was further supported by loading a fluorescent dye, namely calcein, as well as an anti-cancer drug, doxorubicin hydrochloride (DOX), as revealed by UV-vis and emission spectra, and fluorescence microscopy.

Multimodal Interactions of Dopamine Hydrochloride with the Groove Region of DNA: A Key Factor in the Enhanced Stability of DNA.

Nucleic acids (DNA) and neurotransmitters integrate together in the brain of organisms to make powerful information processing systems. Dopamine is an important neurotransmitter whose complexation with DNA in its protonated form has been implemented in several applications such as sensors, antitumor drugs, and bioengineering. However, the molecular level understanding about the binding of protonated dopamine with the different regions of DNA and its effect on the structure as well as stability of DNA is very limited.