Publications by authors named "Abhimanyu Nigam"
Article Synopsis
- Cannabis is a psychoactive drug consumed globally in various forms, with THC being the main active ingredient affecting cognitive and motor functions.
- The legal status of cannabis varies widely, with some regions allowing medicinal use while others, like India, have strict prohibitions, although bhang is culturally accepted.
- A case study highlights a 28-year-old male who suffered a severe heart attack after consuming bhang, illustrating the potential cardiovascular risks associated with cannabis, especially when its concentration is unregulated.
Rare Epithelial Ovarian Cancers: Low Grade Serous and Mucinous Carcinomas.
Cold Spring Harb Perspect Med
September 2023
The ovarian epithelial cancer histotypes can be divided into common and rare types. Common types include high-grade serous ovarian carcinomas and the endometriosis-associated cancers, endometrioid and clear-cell carcinomas. The less common histotypes are mucinous and low-grade serous, each comprising less than 10% of all epithelial carcinomas.
View Article and Find Full Text PDFHormone receptor expression is a characteristic of low-grade serous ovarian carcinoma (LGSOC). Studies investigating estrogen receptor (ER) and progesterone receptor (PR) expression levels suggest its prognostic and predictive significance, although their associations with key molecular aberrations are not well understood. As such, we sought to describe the specific genomic profiles associated with different ER/PR expression patterns and survival outcomes in a cohort of patients with advanced disease.
View Article and Find Full Text PDFArticle Synopsis
- Low-grade serous ovarian carcinoma (LGSOC) shows poor response to chemotherapy, underscoring the importance of genomic analysis to uncover new treatment strategies.
- The study analyzed 71 LGSOC cases, focusing on 127 candidate genes and identifying significant mutations, particularly in RAS/RAF pathway genes and novel drivers like USP9X and MACF1.
- Immunohistochemistry revealed a high positivity rate for hormone receptors and specific protein alterations linked to worse outcomes, suggesting that therapeutic interventions targeting these genomic alterations could improve patient care.