Analytical validation of an ATR-FTIR based method for quantifying the amount of polysorbate 80 adsorbed on PLGA nanoparticles.

Nanoparticle-based drug delivery systems for crossing the blood-brain barrier employ diverse strategies. Coating of nanoparticles with non-ionic surfactants is often employed for enhancing the delivery process. Polysorbate 80 is one of the non-ionic surfactants used as a coating agent for facilitating receptor-mediated endocytosis into the brain.