The pro-/anti-inflammatory effects of different fatty acids on visceral adipocytes are partially mediated by GPR120.

Purpose: This study examines whether G-protein coupled receptor 120 (GPR120) is involved in the pro-/anti-inflammatory effects of different types of fatty acids (FAs) in human visceral adipocytes, and whether these effects may be altered in obesity, a state with a chronic inflammation.

Methods: Pro-/anti-inflammatory effects of palmitic, oleic, linoleic and docosahexaenoic acids on human visceral adipocytes were tested in mature adipocytes from non-obese and morbidly obese (MO) subjects. Also, the effects of these FAs were tested when the GPR120 gene was silenced.

FNDC5 could be regulated by leptin in adipose tissue.

Introduction: Irisin activates the thermogenic function in adipose tissues. However, little is known on the association between human irisin and different cardiometabolic risk factors. We analyse the influence of morbid obesity on irisin levels and its relation with leptin and different cardiovascular risk factors.

Effects of obesity/fatty acids on the expression of GPR120.

Scope: The effects that fatty acids (FAs) exert on G protein-coupled receptor-120 (GPR120) levels, a receptor for FAs, are still unknown. We analyzed the association between GPR120 and obesity, and the FA effects on its expression.

Methods And Results: GPR120 levels were analyzed in visceral adipose tissue (VAT) from nonobese and morbidly obese subject.