Publications by authors named "Abelardo Barbosa Moreira Lima-Neto"
Low-dose candesartan prevents schizophrenia-like behavioral alterations in a neurodevelopmental two-hit model of schizophrenia.
Germana Silva Vasconcelos Manuel Alves Dos Santos Júnior Aline Santos Monte Francisco Eliclécio Rodrigues da Silva Camila Nayane de Carvalho Lima
Prog Neuropsychopharmacol Biol Psychiatry
December 2021
Article Synopsis
- Schizophrenia is a complex mental disorder influenced by various factors, including sex, which affects onset age and symptom severity; researchers used a "two-hit" animal model to study its neurodevelopmental aspects.
- The study revealed different inflammatory and oxidative responses between male and female mice, with males showing more proinflammatory changes, while females exhibited higher nitrite levels and lipid peroxidation.
- Candesartan, a neuroprotective drug, effectively prevented behavioral and neurobiological changes in both sexes, highlighting its potential for further research and prevention strategies in schizophrenia.
Purpose: Type 1 diabetes mellitus (DM1) is one of the most common chronic diseases observed during childhood. The incidence of DM1 is increasing worldwide, and there is currently no way to prevent or delay the onset or to cure the disease. Most diseases, including diabetes, stem from abnormalities in the functioning of proteins, and some studies have reported the expression of protein variation to be involved in the development of DM1.
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