[Peritoneal mesothelioma revealed by episodes of recurrent spontaneous peritonitis].

A case of a malignant peritoneal mesothelioma revealed by recurrent episodes of peritonitis is reported. This presentation had never been described. A 54 year-old man presented successive episodes of appendicitis, cholecystitis and sigmoiditis associated with purulent aseptic peritonitis.

[The Cordeliers University Center. A short guide for a visitor].

The history of the Pierre and Marie Curie University Cordeliers Center is summarized. A few traces of the history of this part of the latin quarter still remain. The oldest souvenir is the plain but impressive Refectory of the Cordeliers.

Time-course development of differentiated hepatocarcinoma and lung metastasis in transgenic mice.

A precise targeting of the SV40 T early region expression in the liver of transgenic mice was obtained using 700 bp of the antithrombin III regulatory sequences to control oncogene expression. In the strain expressing the highest level of large T antigen (Tag), the incidence of hepatocarcinoma was 100%. The evolution was reproducible and characterized by a marked cytolysis occurring as early as 4 weeks, when no morphological and histological modifications were visible, a preneoplastic state marked by a progression from hyperplasia to proliferative nodules composed of highly differentiated cells exhibiting a high Tag expression, which elicited tumor formation in nude mice and could proliferate in vitro, and hepatocellular carcinoma associated, in 10% of the cases, with lung metastasis.

Bone allografts sterilised by irradiation. Biological properties, procurement and results of 150 massive allografts.

Massive bone allografts from cadavers have been sterilised by gamma-radiation from radioactive cobalt at a dose of 25,000 gray (Gy). The biological effects of radiation are discussed. Human cortical bone showed an acceptable 20% decrease in strength on bending tests after 27,000 Gy irradiation, but higher doses are more damaging and should be avoided.

Castleman's disease of the leptomeninges. Report of three cases.

Castleman's disease is a rare, benign lymphoproliferative disorder that usually arises in lymph nodes, most commonly in the mediastinum. The authors report the clinical and pathological features of three patients with localized Castleman's disease of the leptomeninges. There were two women, aged 63 and 82 years, and one 25-year-old man.

[Bone resorption and remodelling in chondrosarcomas of the limbs and pelvis. Diagnostic value in 84 cases].

Aside well known histological and cytological arguments of malignancy, we have analysed the tumoral growth and invasion in periphery for the skeletal chondrosarcoma diagnosis. This study involves 84 cases of chondrosarcoma of limbs, and pelvic limb selected from 176 cases of chondrosarcoma seen in the Cochin hospital. The following constatations were made: the tumor growth is fast in a chondrosarcoma and the lesions are continuous; in a same case, we can assist to tumoral invasion signs and bone reparation signs.

[Double mitral orifice. An anatomical case].

A double mitral orifice was discovered at autopsy in a 74 year old woman. Death resulted after several episodes of cardiac failure complicating mixed mitral and aortic valve disease. A vertical limbus bridged the mitral annulus separating it into two distinct right and left orifices, with oblique long axes aligned towards the lower part of the limbus perpendicular to each other from the left atrial view.

Frequency and diagnostic value of the virus-like filamentous intranuclear inclusions in giant cell tumor of bone, not associated with Paget's disease. A study of 43 cases.

This paper deals with the paramyxovirus-like intranuclear inclusions observed in giant cells tumours of bone (GCTB). Twenty-one (49%) of 43 cases of GCTB (1977-1985), either fresh and/or cultured, show these ultrastructural inclusions. Fifty samples of various bone lesions in which giant cell lesions occurred, including aneurysmal cysts, hyperparathyroidism, osteoblastoma, human and rat osteopetrosis, GCT of tendon sheaths, and non skeletal granuloma were used as controls.

Multifocal nonosteogenic fibroma: report of a case with ultrastructural findings.

The case of a patient in whom multiple nonosteogenic fibromas developed is reported. This condition is very unusual and must be differentiated not only from the multiple lesions that occur in association with well-known entities but also from some occasionally multifocal bone tumors. The lesion is characterized by proliferations of spindle cells disposed in storiform patterns, with numerous scattered multinucleated giant cells.

[Hip surgery: local tissue reactions].

Present extent of total hip prostheses, protracted course of first operations lead to pathological studies on local tissue reactions, sign of the failure or of the damaging of the artificial hip. Another pathology, often as intricate, is observed after more conservative surgery: high femoral osteotomies, cup arthroplasties, femoral metallic prostheses. Failure of an high femoral osteotomy shows a running of osteoarthritic lesions the topography of which is always modified by the new orientation of the articular bearing segment.

[Sea-blue histiocyte syndrome. Review of the literature apropos of a case of idiopathic splenomegaly in the adult].

A case of idiopathic splenomegaly with ceroid histiocytosis--the so-called sea-blue histiocytosis--is reported with reference to the literature. The histological, histochemical and ultrastructural features of stained sea-blue and ceroid-containing macrophages are described and their physiopathological significance is discussed. Attention is drawn to the distinctions, between idiopathic and secondary or associated forms, and the practical value of the pathological diagnosis is emphasized.

[Giant fibroma of the pleura. Apropos of 2 cases].

Two cases are reported of giant pleural fibroma (2.9 and 4.2 kg), of slow growth (both had been present for 17 years), developing in the parietal pleura in a 56-year-old woman and in the triangular ligament of a 35-year-old man respectively, and treated by surgical excision.

[Rheumatoid polyarthritis with Gougerot-Sjögren's syndrome, pulmonary pseudolymphoma and digestive lymphoma. Apropos of a case].

The authors report a case of the Gougerot-Sjögren syndrome with rheumatoid arthritis, of particular interest because of lymphocytic proliferation. This was initially confined to the broncho-pulmonary tissues with histological appearances of pseudo-lymphoma, a diagnosis supported by clinical regression with immunosuppressive drugs, over a 5 years period. This difficult diagnosis needs histological, biochemical and clinical confirmation and, the very existence of this entity is debatable.

[Congenital mesoblastic nephroma. Study of five cases and review of the literature (author's transl)].

Mesoblastic nephroma (individualized by Bolande in 1967) is a congenital renal tumor sometimes locally and regionally aggressive but never giving metastases, in contrast with nephroblastoma. It almost always occurs in the newborn. Therefore, every renal tumor discovered before twelve months must evoke mesoblastic nephroma.

[Blood group ABO (H) cell surface antigens in bladder tumours invading the chorion. Prognostic value of their determination by immunofluorescence. Retrospective study of one hundred and twenty-five cases].

The authors have studied 125 stage A bladder tumours with a follow-up period of at least 5 years. The ABH cell surface antigens were collected by a double-layer immunofluorescence technique which has already been described. All the cross sections were read by the same pathologist who knew nothing about the clinical developments.

[Spironolactone bodies. Light and electron microscope study apropos of 4 cases of adrenal adenomas with primary hyperaldosteronism].

So-called Spironolactone bodies are reported in four adrenal cortical adenomas that were removed from patients with primary hyperaldosteronism, treated preoperatively with spironolactone. Their morphology is described optically : these round acidophilic cytoplasmic bodies have a laminated appearance that ranges in size from 2 to 20 mu in diameter. Electron microscopy of the zona glomerulosa non adenomatous cells and of adenomatous cells of glomerular type reveals numerous membranes arranged concentrically around a central core.

[Tubular filamentous intranuclear inclusions on multinucleated cells of bone giant cell tumors].

Electron microscopy revealed tubular filamentous inclusions within nuclei of giant cells in 22 per cent of 31 cases of genuine giant cell tumours of bone. These inclusions are, both on biopsy and on culture, similar to those of osteoclasts of Paget's disease but less constant, less numerous and mainly intranuclear. Controls by the study of giant multinucleated cells from osseous and extra osseous lesions were negative.