Publications by authors named "Abel Roscoe"
A hydrolyzed N-propionylthiosuccinimide linker is cleaved by metastable fragmentation, increasing reliability of conjugation site identification in conjugate vaccines.
Pablo E Ramos-Bermúdez Satomy Pousa Paulo Carvalho Rodrigo Soares Caldeira Brant Michel Batista Abel Roscoe
Rapid Commun Mass Spectrom
September 2024
Article Synopsis
- Conjugate vaccines have special places (conjugation sites) that help them work better, and finding these sites is very important for their quality.
- Scientists used advanced techniques like mass spectrometry (MS) to study certain peptides and confirm how they break apart to reveal these conjugation sites.
- The study showed that a specific linker in these peptides can be easily broken down, allowing better identification of conjugation sites, which could lead to stronger vaccines in the future.