Publications by authors named "Abel N"
Background: The study investigates the prognostic impact of sex and sex-related differences in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF). More data regarding the characterization of patients and their outcomes in the presence of HFmrEF are needed.
Methods And Results: Consecutive patients hospitalized with HFmrEF (ie, left ventricular ejection fraction 41%-49% and signs or symptoms of HF) were retrospectively included at one institution from 2016 to 2022.
Objective: The study investigates the prognostic impact of dyskalemias in patients hospitalized with heart failure with mildly reduced ejection fraction (HFmrEF).
Background: Although dyskalemias represent a common complication in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF), data concerning the prevalence and prognostic impact of dyskalemias in HFmrEF is limited.
Methods: Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022.
This study investigates age-related differences and outcomes in patients hospitalized with heart failure with a mildly reduced ejection fraction (HFmrEF). The characterization of patients with HFmrEF and the prognostic value of age has rarely been investigated. Patients with HFmrEF were retrospectively included at one institution between 2016 and 2022.
View Article and Find Full Text PDFBackground: Mounting evidence suggests that vitamin D deficiency is associated with a higher risk of many chronic non-skeletal, age-associated diseases as well as mortality.
Aim: To determine, in older patients aged ≥ 80, the prevalence of vitamin D deficiency and its association with comorbidity, laboratory tests, length of stay and mortality within one year from blood withdrawal on admission to acute geriatrics ward.
Methods: We retrospectively surveyed electronic hospital health records of 830 older patients.
Objective: This study investigates the prevalence and prognostic impact of diastolic dysfunction (DD) in patients hospitalized with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) in sinus rhythm.
Background: Data regarding the prognostic impact of DD in patients with HFmrEF is limited.
Methods: From 2016 to 2022, all patients hospitalized with HFmrEF (i.
Objective: The study investigates the characteristics and prognostic impact of different heart failure (HF) etiologies in patients with heart failure with mildly reduced ejection fraction (HFmrEF).
Background: Data regarding the characterization of patients with HFmrEF and their outcomes is scarce.
Methods: Consecutive patients with HFmrEF (i.
Aims: Data regarding the characterization and outcomes of patients with heart failure (HF) with mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates the characteristics and prognostic impact of native aortic valve diseases (AVD) in patients with HFmrEF.
Methods And Results: Consecutive patients hospitalized with HFmrEF (i.
Aims: The study investigates the prognosis of atrial fibrillation (AF) in patients with heart failure with mildly reduced ejection fraction (HFmrEF). Data concerning the prognostic impact of AF in patients with HFmrEF is scarce.
Methods And Results: Consecutive patients with HFmrEF [i.
: The occurrence of ventricular tachyarrhythmias represents an established risk factor of mortality in heart failure (HF). However, data concerning their prognostic impact in heart failure with mildly reduced ejection fraction (HFmrEF) is limited. Therefore, the present study aims to investigate patient characteristics associated with ventricular tachyarrhythmias and their prognostic impact in patients with HFmrEF.
View Article and Find Full Text PDFObjective: The study investigates the prognostic impact of the severity and etiology of chronic kidney disease (CKD) in patients with heart failure with mildly reduced ejection fraction (HFmrEF).
Background: Data regarding the outcomes in patients with CKD in HFmrEF is scarce.
Methods: Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022.
Article Synopsis
- The study examines how previous left ventricular ejection fraction (LVEF) affects prognosis in patients with mildly reduced ejection fraction (HFmrEF) heart failure, a condition often overlooked in terms of prognostic impact.
- It retrospectively analyzed 689 patients from 2016 to 2022, categorizing them into three groups based on changes in LVEF: stable, improved, and deteriorated.
- Results showed no significant differences in all-cause mortality or hospital readmissions among the groups at 12 and 30 months, indicating that changes in LVEF do not significantly influence patient outcomes in this population.
Objective: The present study aims to clarify the prevalence and prognostic impact of anaemia and iron deficiency in patients with heart failure with mildly reduced ejection fraction (HFmrEF).
Background: The prognostic impact of anaemia and iron deficiency in HFmrEF has not yet been clarified.
Methods: Consecutive patients with HFmrEF were retrospectively included at one institution from 2016 to 2022.
Article Synopsis
- Mitral valve regurgitation (MR) is prevalent among patients with mildly reduced ejection fraction heart failure (HFmrEF), yet data on its impact is limited.
- A study of over 2,000 hospitalized HFmrEF patients found that those with MR had significantly higher risk of all-cause mortality and hospital readmissions for worsening heart failure compared to those without MR.
- The findings also indicated that the severity of MR correlates with increased mortality risk, and secondary MR is associated with better outcomes than primary MR.
Aims: The study sought to comprehensively investigate the effect of heart failure (HF) pharmacotherapies in patients with HF with mildly reduced ejection fraction (HFmrEF). In the absence of randomized controlled trials, guideline recommendations concerning HF-related therapies in patients with HFmrEF are limited.
Methods And Results: Consecutive patients hospitalized with HFmrEF were retrospectively included at one institution from 2016 to 2022.
Article Synopsis
- The study looked at how body mass index (BMI) affects patients with heart failure who have mildly reduced heart function.
- It found that patients with lower BMI had a higher chance of dying within 30 months compared to those with higher BMI.
- This suggests that being overweight might actually help some patients with this type of heart failure live longer, which is called the "obesity paradox."
Phosphorylation of the alpha-I motif in SYMRK drives root nodule organogenesis.
Proc Natl Acad Sci U S A
February 2024
Symbiosis receptor-like kinase SYMRK is required for root nodule symbiosis between legume plants and nitrogen-fixing bacteria. To understand symbiotic signaling from SYMRK, we determined the crystal structure to 1.95 Å and mapped the phosphorylation sites onto the intracellular domain.
View Article and Find Full Text PDFBackground: Data regarding the characterization and outcomes of diabetics with heart failure with a mildly reduced ejection fraction (HFmrEF) is scarce. This study investigates the prevalence and prognostic impact of type 2 diabetes in patients with HFmrEF.
Methods: Consecutive patients with HFmrEF (i.
Article Synopsis
- * It included 2,184 patients, revealing that those with COPD had a higher risk of all-cause mortality (45% vs. 30%) and re-hospitalization due to worsening heart failure compared to those without COPD.
- * The findings suggest that COPD significantly worsens outcomes for patients hospitalized with HFmrEF, indicating a need for targeted management strategies for this population.
Article Synopsis
- Cardiac remodeling happens in people with heart failure (HF) and helps doctors see how serious the disease is.
- A study looked at 1881 patients with a specific type of heart failure (called HFmrEF) from 2016 to 2022 to see how septal hypertrophy (a condition where part of the heart muscle gets thicker) affected them.
- Although having septal hypertrophy wasn't linked to higher death rates, it was connected to a higher chance of being hospitalized again due to heart problems in the following months.
Article Synopsis
- This study examines the effectiveness of NT-proBNP as a biomarker for diagnosing and predicting outcomes in patients with heart failure and mildly reduced ejection fraction (HFmrEF), focusing on their kidney function (eGFR).
- Among the 755 patients analyzed, those with acute decompensated heart failure (ADHF) showed significantly higher NT-proBNP levels compared to those without, indicating its potential as a diagnostic tool.
- Higher NT-proBNP levels (> 3946 pg/mL) were linked to increased rates of death over 30 months, but its predictive value was diminished in patients with severely reduced kidney function (eGFR < 30 mL/min).
Background: Lung cancer screening with low-dose computed tomography for high-risk populations is being implemented in the UK. However, inclusive identification and invitation of the high-risk population is a major challenge for equitable lung screening implementation. Primary care electronic health records (EHRs) can be used to identify lung screening-eligible individuals based on age and smoking history, but the quality of EHR smoking data is limited.
View Article and Find Full Text PDFPrognostic impact of acute decompensated heart failure in patients with heart failure with mildly reduced ejection fraction.
Eur Heart J Acute Cardiovasc Care
February 2024
Article Synopsis
- This study looked at how acute decompensated heart failure (ADHF) affects patients who have heart failure with mildly reduced ejection fraction (HFmrEF).
- Researchers found that patients with ADHF had a much higher chance of dying or being hospitalized again compared to those without ADHF.
- The conclusion is that having ADHF is common and makes health outcomes worse for patients with HFmrEF.
For decades, Agrobacterium rhizogenes (now Rhizobium rhizogenes), the causative agent of hairy root disease, has been harnessed as an interkingdom DNA delivery tool for generating transgenic hairy roots on a wide variety of plants. One of the strategies involves the construction of transconjugant R. rhizogenes by transferring gene(s) of interest into previously constructed R.
View Article and Find Full Text PDFBackground: Coaches are pivotal in the management of concussed players. Assessing the knowledge of high school rugby coaches with regard to concussion management will enable relevant future education on this topic to be covered.
Objectives: To investigate the knowledge of South African high school rugby coaches on concussion symptom recognition, knowledge and stepwise return-to-play (RTP) protocols.
Understanding the composition and activation of multicomponent receptor complexes is a challenge in biology. To address this, we developed a synthetic approach based on nanobodies to drive assembly and activation of cell surface receptors and apply the concept by manipulating receptors that govern plant symbiosis with nitrogen-fixing bacteria. We show that the Nod factor receptors NFR1 and NFR5 constitute the core receptor complex initiating the cortical root nodule organogenesis program as well as the epidermal program controlling infection.
View Article and Find Full Text PDF