Publications by authors named "Abel Castrillo"
Despite recent advances in the identification of the cytogenetic profiles of meningiomas, a significant group of tumors still show normal karyotypes or few chromosomal changes. The authors analyzed the cytogenetic profile of 50 meningiomas using fluorescence in situ hybridization and high-density (500 K) single nucleotide polymorphism (SNP) arrays. Our results confirm that del(22q) (52%) and del(1p) (16%) (common deleted regions: 22q11.
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- Researchers analyzed gene expression profiles (GEP) of 40 glioma tumors to explore their relation to cytogenetics and histopathology.
- They found significant differences in GEP between low- and high-grade gliomas, identifying key genes linked to cell growth, death, DNA repair, and signaling pathways.
- Among glioblastoma multiforme (GBM), three tumor subgroups were categorized based on their GEP, which corresponded to specific genetic alterations, suggesting a strong link between gene expression and tumor characteristics.
Cytogenetic analysis is a powerful tool for predicting recurrence in meningiomas, even among histologically benign/grade I tumors. Despite this, no study has been reported in which the impact of tumor cytogenetics on the gene expression profiles (GEP) has been analyzed in meningiomas. Here, we analyzed the GEP of 47 tumors and correlated them with the most clinical relevant cytogenetic subgroups of meningiomas, as confirmed through the analysis of 172 patients.
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