Risk adapted combined modality treatment in children with Hodgkin's disease: NCI, Cairo.

Objective: The objective of this study is to maximize the chance of cure while minimizing surgery, radiotherapy and chemotherapy as much as possible to avoid late effects and toxicity of combined modality treatment in children with Hodgkin's disease.

Patients And Methods: One hundred twenty-one (121) children under the age of 18 years with a histopathologic diagnosis of Hodgkin's disease were enrolled into this study. Patients were stratified according to stage into 3 risk groups: low (Stages: I, II A), intermediate (Stages: II B, III A) and high risk group (Stages: III B, IV).