The study explores the protective effects of curcum against cancer by evaluating its impact on rats exposed to nitrosamine precursors and E. coli infections.
Rats were divided into three groups: a normal control, a group treated with nitrosamines and E. coli, and a group that received both nitrosamines, E. coli, and curcum.
Results showed that rats in the curcum group had fewer urinary bladder lesions and lower levels of NF-κB, Bcl-2, and IL-6, indicating curcum's potential to inhibit bladder cancer development through the NF-κB pathway.
Background: Bladder cancer is a common malignancy in Egypt. A history of urinary tract infection can be considered as a risk factor for bladder cancer. Escherichia coli (E.