The combination of omega-3 fatty acids with high doses of vitamin D3 elevate A1c levels: A randomized Clinical Trial in people with vitamin D deficiency.

Purpose: This randomised clinical trial (RCT) was created to assess the influence of 1,25-dihydroxyvitamin D (VD ), omega-3 fatty acids (n-3FA) and their combination (D+) on glycated haemoglobin (A1c) levels in Jordanian peoples with vitamin D deficiency (VDD).

Participants And Methods: This RCT was designed to examine the follow-up (2 months) effect of either 50 000 IU VD , 300 mg n-3FA, or the combination of the two supplements on glycated Haemoglobin (A1c) levels in 146 Jordanian women and men with VDD, aged from 25 to 55 years. The eligible participants were randomised into four groups: Control (C); VD supplementation (50 000 IU of VD was taken weekly) (D ); n-3FA supplementation (300 mg of omega-3FA was taken daily) (n-3FA); VD and omega-3 supplementation group (D+) with the same protocol as the previous two groups.