Publications by authors named "Abeer Al-Sarraj"
Background: Previous studies have reported higher circulating bile acid levels in patients with HCC compared to healthy controls. However, the association between prediagnostic bile acid levels and HCC risk among patients with cirrhosis is unclear.
Methods: We measured total BA (TBA) concentration in serum samples collected from a prospective cohort of patients with cirrhosis who were followed until the development of HCC, death, or last study date.
Risk Stratification Model for Hepatocellular Cancer in Patients With Cirrhosis.
Clin Gastroenterol Hepatol
December 2023
Background & Aims: The available risk stratification indices for hepatocellular cancer (HCC) have limited applicability. We developed and externally validated an HCC risk stratification index in U.S.
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- Polygenic risk scores (PRS) show potential for improving the prediction of hepatocellular cancer (HCC) risk, but existing data primarily focuses on European populations, leaving a gap in multiethnic U.S. patient research.
- A study involving 1,644 cirrhosis patients revealed that higher PRS correlates with increased HCC risk—specifically, a 134% risk increase per higher PRS unit and a two-fold risk in the highest PRS group compared to the lowest.
- While the PRS alone had modest predictive accuracy, integrating it with traditional risk factors improved the model's predictive ability, suggesting PRS could enhance risk stratification for HCC among diverse cirrhosis patients in the
Background And Aims: Etiological risk factors for cirrhosis have changed in the last decade. It remains unclear to what extent these trends in cirrhosis risk factors have changed HCC risk.
Approach And Results: We used data from two contemporary, prospective multiethnic cohorts of patients with cirrhosis: the Texas Hepatocellular Carcinoma Consortium Cohort and the Houston Veterans Administration Cirrhosis Surveillance Cohort.