Publications by authors named "Abeer A Altamimi"
The goal of the research was to develop a hydrophobic octanoate salt of chitosan (CS-OA) and use the salt as a nanoparticle platform for the delivery of curcumin (CUR) into prostate cancer cells. The nanoprecipitation technique was used to prepare the nanoparticles, which were measured for particle size and encapsulation efficacy relative to CUR-CS nanoparticles. The cytotoxicity of CUR-OA-CS nanoparticles was evaluated in prostate cancerous cells (PC3 and DU145) in comparison with the corresponding blank nanoparticles and hydroalcoholic CUR solution.
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- Empagliflozin (EMP) has poor safety and efficacy due to rapid distribution and low solubility, but a new oral long-acting raft-forming nano gel can enhance its dissolution when combined with coated nanoparticles.
- The study found that these EMP nanoparticles demonstrated increased solubility in acidic conditions, significantly improving their potential for use in cancer treatment.
- Characterization of the nanoparticles indicated effective polymeric coating and the gel formulation shows promise as a targeted oral treatment for stomach cancer and related inflammation.
To address the prevalent genistein (GST) metabolism and inadequate intestinal absorption, an oral long-acting and gastric in-situ gelling gel was designed to encapsulate and localize the intestinal release of the loaded genistein-ginseng (GST-GNS) solid dispersion. Because of the high breast perfusion of GST upon oral absorption, the GST-GNS solid dispersion was developed to enhance GST's dissolution and penetration while offering a synergistic impact against breast cancer (BC). Physiochemical analysis of the GST-GNS solid dispersion, release analysis, gel characterizations, storage stability, penetration, and in vitro cytotoxicity studies were carried out.
View Article and Find Full Text PDFThis study was designed to investigate the level and associations of physical activity, sedentary behavior, sleep, and dietary habits among Saudi women attending fitness centers in Riyadh. A descriptive cross-sectional study was carried out from 12 fitness centers in Riyadh, Saudi Arabia. A total of 460 participants answered a two-part survey self-administered questionnaire, which included information about the demographic characteristics and lifestyle.
View Article and Find Full Text PDFObjective: To examine body image perception and the associations of body dissatisfaction (BD) with socio-demographic and lifestyle factors among Saudi women attending fitness centers in Riyadh.
Methods: Saudi females aged 16 years and older were recruited from 12 randomly selected fitness centers in Riyadh, using stratified clustered sampling technique ( = 460). Height and weight were measured to calculate actual body mass index (BMI).
Objective: To examine the associations of overweight or obesity with several lifestyle and socio-demographic factors among Saudi women attending fitness centers in Riyadh.
Methods: Saudi females (n = 460) aged 16 years and older were recruited from 12 randomly selected fitness centers in Riyadh, using a stratified clustered sampling technique. Bodyweight and height were measured.