A translatable predictor of human radiation exposure.

Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate biodosimetry of thousands of potentially affected individuals will be essential for effective medical management to occur. Currently, health care providers lack an accurate, high-throughput biodosimetric assay which is suitable for the triage of large numbers of radiation injury victims.

Comparison on information-seeking behavior of postgraduated students in Isfahan University of Medical Sciences and University of Isfahan in writing dissertation based on Kuhlthau model of information search process.

Introduction: Information-seeking behaviors have been one of the main focuses of researchers in order to identify and solve the problems users face in information recovery. The aim of this research is Comparative on Information-Seeking Behavior of the Postgraduate Students in Isfahan University of Medical Sciences and Isfahan University in Writing Dissertation based on Kuhlthau Model of Information Search Process in 2012.

Materials And Methods: The research method followed is survey and the data collection tool is Narmenji questionnaire.

Biologic activity of porphyromonas endodontalis complex lipids.

Introduction: Periapical infections secondary to pulpal necrosis are associated with bacterial contamination of the pulp. Porphyromonas endodontalis, a gram-negative organism, is considered to be a pulpal pathogen. P.

Therapeutic benefit of bortezomib on acute graft-versus-host disease is tissue specific and is associated with interleukin-6 levels.

Bortezomib, a proteasome inhibitor capable of direct antitumor effects, has been shown to prevent acute graft-versus-host disease (GVHD) when administered in a short course immediately after bone marrow transplantation (BMT) in mice. However, when bortezomib is given continuously, CD4(+) T cell-mediated gastrointestinal tract damage increases GVHD mortality. To investigate the protective effects of bortezomib on other organs, we used a CD8-dependent acute GVHD (aGVHD) model of C3H.

Treatment of chronic graft-versus-host disease with bortezomib.

Chronic graft-versus-host disease (cGVHD) following allogeneic hematopoietic stem cell transplantation (HSCT) has emerged as a predominant complication following HSCT and has a distinct etiology. We and others have previously demonstrated that bortezomib, a proteasome inhibitor, can prevent but not treat acute GVHD in mice. To assess the effects of bortezomib on cGVHD, a mouse minor histocompatibility antigen-mismatched strain combination was used to mimic clinical cGVHD sclerodermatous pathogenesis and phenotype.

Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013.

Recently, the gene therapy field has begun to experience clinical successes in a number of different diseases using various approaches and vectors. The workshop Gene Therapy: Charting a Future Course, sponsored by the National Institutes of Health (NIH) Office of Biotechnology Activities, brought together early and mid-career researchers to discuss the key scientific challenges and opportunities, ethical and communication issues, and NIH and foundation resources available to facilitate further clinical advances.

Relationship between breast arterial calcification on mammography with CT Calcium scoring and coronary CT angiography results.

Background: Mammography as a non invasive method has been suggested to be helpful in predicting coronary artery disease. This study aimed to investigate whether presence and severity of breast artery calcification (BAC) on mammograms is associated with computed tomography coronary angiography (CTCA) finding such as coronary artery calcium (CAC) score and the severity of coronary artery stenosis.

Materials And Methods: This cross-sectional study was performed on 150 women aged >40 years who were referred for CTCA.

Lenalidomide plus rituximab can produce durable clinical responses in patients with relapsed or refractory, indolent non-Hodgkin lymphoma.

This phase II study evaluated the safety and efficacy of lenalidomide in combination with rituximab in patients with relapsed/refractory, indolent non-Hodgkin lymphoma (NHL). Patients were treated with daily lenalidomide in 28-d cycles and weekly rituximab for 4 weeks. Lenalidomide was continued until progression or unacceptable toxicity.

Analytical solution for the free vibration analysis of delaminated Timoshenko beams.

This work presents a method to find the exact solutions for the free vibration analysis of a delaminated beam based on the Timoshenko type with different boundary conditions. The solutions are obtained by the method of Lagrange multipliers in which the free vibration problem is posed as a constrained variational problem. The Legendre orthogonal polynomials are used as the beam eigenfunctions.

Outcome of vesicoureteral reflux in infants: impact of prenatal diagnosis.

Objective: Vesicoureteral reflux (VUR) is an important disorder that could be diagnosed in antenatal or postnatal period. The natural history of VUR seems to be different between prenatal or postnatal forms of the disease. We compared the natural history and outcome of vesicoureteral reflux in infants less than one year old diagnosed prenatally or postnatally.

The role of urinary TIMP1 and MMP9 levels in predicting vesicoureteral reflux in neonates with antenatal hydronephrosis.

Background: Antenatal hydronephrosis (AH) is commonly found on evaluation of pregnant women and 20-30 % of neonates have vesicoureteral reflux (VUR). In order to diagnose VUR, we required invasive testing and exposure of the neonate to radiation. The concentrations of a matrix metalloproteinase, MMP9, and its inhibitor TIMP1, were analyzed in hydronephrotic newborns with VUR and were compared to those without reflux.

mRNA expression profile of multidrug-resistant genes in acute lymphoblastic leukemia of children, a prognostic value for ABCA3 and ABCA2.

Multidrug resistance (MDR) is an important cause of treatment failure in acute lymphoblastic leukemia (ALL). The ABC family of membrane transporters is proposed, albeit with controversy, to be involved in this process. The present study aims to investigate the mRNA expression profile of several genes of this family, including ABCA2, ABCA3, ABCB1/MDR1, MRP1/ABCC1, MRP3/ABCC3, ABCG2/BCRP, and the intracellular transporter MVP/LRP, in childhood ALL, and to evaluate their association with response to therapy.

Multiple infusions of CD20-targeted T cells and low-dose IL-2 after SCT for high-risk non-Hodgkin's lymphoma: a pilot study.

A pilot phase I clinical trial involving 15 infusions of anti-CD3 × anti-CD20 bispecific Ab (CD20Bi)-armed anti-CD3-activated T cells (aATC) and low-dose IL-2 was conducted in three non-Hodgkin's lymphoma (NHL) patients (two high-risk and one refractory) after autologous SCT. The feasibility of T-cell expansion, safety of aATC infusions, cytotoxic immune responses and trafficking of aATC were evaluated. Three NHL patients received 15 infusions of 5 × 10(9) aATC (three infusions/week for 3 weeks and one infusion/week for 6 weeks) between days 1 and 65 after SCT with IL-2.

The path(way) less traveled.

In this issue of Blood, Mathewson et al characterized targeting a novel intracellular pathway with an agent known to induce potent antitumor effects but now also appears to potently suppress inflammatory responses by dendritic cells (DCs) and prevent graft-vs-host disease (GVHD). Identifying agents that can suppress GVHD yet not compromise graft-vs-tumor (GVT) effects remains a paramount goal in allogeneic hematopoietic stem cell transplantation (HSCT).

Theoretical studies on the tautomerism of tetrazole selenone.

The tautomerism of all possible forms of tetrazole selenone (A-G), induced by proton transfer, was studied, theoretically, in different environments including gas phase, continuum solvent and microsolvated environment with one or two explicit water or ammonia molecules. The calculations were performed using two different levels of theory including mPW2PLYP and DFT-B3LYP. The 6-311++G(d,p) basis set was used for C, H, O and N and the standard relativistic effective core pseudo potential LANL2DZ basis set was used for Se atom.

An intracystic papillary carcinoma of the breast.

Intracystic carcinoma of the breast is a rare form of breast carcinoma. Among allmalignant breast tumors, this lesion has an incidence of 0.2-0.

Acidity constants of some sulfur oxoacids in aqueous solution using CCSD and MP2 methods.

The calculations of the acidity constants (pKa) of a series of sulfur oxoacids including H2SOn (n = 1-5) and H2S2On (n = 1, 3, 4, 6 and 7) are presented for the first time. The calculations were performed using two expensive correlated levels of theory including MP2/6-311++G(3df,3pd) and CCSD/6-311++G(d,p) in both gas and aqueous phases. The new continuum solvation model, SMD, based on the quantum mechanical charge density of a solute molecule interacting with a continuum description of the solvent, used to account the solvent effects.

A Preliminary Study on the Effects of Attachment-based Intervention on Pediatric Obsessive-Compulsive Disorder.

Background: Research on attachment has shed new light on understanding one of the underlying mechanisms of psychopathology in children. The aim of this study was to investigate the therapeutic efficacy of attachment-based intervention in a pediatric sample with obsessive-compulsive disorder (OCD).

Methods: Twelve participants, 10-12 years of age, were treated across an eight-week period.

Gene therapy clinical trials worldwide to 2012 - an update.

To date, over 1800 gene therapy clinical trials have been completed, are ongoing or have been approved worldwide. Our database brings together global information on gene therapy clinical trials from official agency sources, published literature, conference presentations and posters kindly provided to us by individual investigators or trial sponsors. This review presents our analysis of clinical trials that, to the best of our knowledge, have been or are being performed worldwide.

The validity of MRI in evaluation of tumor response to neoadjuvant chemotherapy in locally advanced breast cancer.

Background: Physical Examination (PE) and breast MRI are two of the currentmethods which have usually used in diagnosis of primary breast cancer. Their accuracy in detection of: either complete response or presence of residual tumor, however, has not yet been established in patients who have been received Neoadjuvant Chemotherapy (NAC).The purpose of this study was to evaluate the diagnostic accuracy of breast MRI in assessment of residual neoplastic tissue after NAC in patients with Locally Advanced Breast Cancer (LABC).

Preparation and pathogen inactivation of double dose buffy coat platelet products using the INTERCEPT blood system.

Blood centers are faced with many challenges including maximizing production yield from the blood product donations they receive as well as ensuring the highest possible level of safety for transfusion patients, including protection from transfusion transmitted diseases. This must be accomplished in a fiscally responsible manner which minimizes operating expenses including consumables, equipment, waste, and personnel costs, among others. Several methods are available to produce platelet concentrates for transfusion.

Resistive index of the remaining kidney in allograft kidney donors.

Objectives: Kidney transplant is the last resort in patients with end-stage renal disease. In living-kidney donors undergoing nephrectomy for transplant; however, morphologic and hemodynamic changes may occur in the remaining kidney with time. If there would be such a change, then it may alter the diagnostic utility of Doppler ultrasound in evaluating diseased conditions of the solitary kidney.

Ergonomic and anthropometric consideration for library furniture in an Iranian public university.

Background: In our competing educational world, students spend a considerable part of their daily life, studying at library furniture. Not surprisingly, due to lack of proper anthropometric databases, these products have typically been ill fitted for the intended user populations.

Objective: To verify the optimum anthropometric match of library furniture within an academic environment, through a combined qualitative and quantitative approach.