Publications by authors named "Abed Pablo"
Background: Reflexive laboratory testing workflows can improve the assessment of patients receiving pain medications chronically, but complex workflows requiring pathologist input and interpretation may not be well-supported by traditional laboratory information systems. In this work, we describe the development of a web application that improves the efficiency of pathologists and laboratory staff in delivering actionable toxicology results.
Method: Before designing the application, we set out to understand the entire workflow including the laboratory workflow and pathologist review.
Listening to your mass spectrometer: An open-source toolkit to visualize mass spectrometer data.
J Mass Spectrom Adv Clin Lab
January 2022
Introduction: We have developed a set of tools built with open-source software that includes both a database and a visualization component to collect LC-MS/MS data and monitor quality control parameters.
Description Of Tool: To display LC-MS/MS data we built a parsing tool using Python and standard libraries to parse the XML files after each clinical run. The tool parses the necessary information to store a database comprised of three distinct tables.
Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome.
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- Immunosuppressant medications work by dampening the immune system to prevent organ rejection in transplants and treat autoimmune diseases like lupus and rheumatoid arthritis.
- Quantifying these drugs in the blood is crucial for effective treatment and to prevent toxicity or side effects.
- The text outlines a proven method for measuring levels of specific immunosuppressants, including cyclosporine A, tacrolimus, sirolimus, and everolimus, which has been used in clinical settings for several years.
Background: Dried specimens have been proposed in multiple environments to minimize costs associated with specimen storage and shipping in clinical studies. This report describes the development and validation of an automated method for qualitative toxicology screening of dried urine samples using LC-MS/MS.
Methods: Urine standards containing 41 compounds were prepared and applied to filter paper cards.