Proarrhythmogenic Effect of the L532P and N588K Mutations in the Human Heart Using a 3D Electrophysiological Model.

Background: Atrial arrhythmia is a cardiac disorder caused by abnormal electrical signaling and transmission, which can result in atrial fibrillation and eventual death. Genetic defects in ion channels can cause myocardial repolarization disorders. Arrhythmia-associated gene mutations, including gene mutations, which are one of the most common genetic disorders, have been reported.