Publications by authors named "Abduzhappar Gaipov"

In this work, Brillouin light-scattering spectroscopy and optical backscattering reflectometry (OBR) using Mg-silica-NP-doped distributed sensing fibers were employed for monitoring local GHz visco-elastic properties and surface temperature, respectively, laser driven heating and ablation of chicken tissues. The spatial temperature distribution measured by OBR at various infrared laser heating powers and times was used to validate spatio-temporal local temperature variations modeled by the finite element method via solving Pennes' bioheat conduction equation. The reduction of viscosity and stiffness in chicken skin during its laser heating was attributed to water loss, protein denaturation and change in lipid phase behavior.

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Background: Central Asia is known to face various ecological challenges that constitutes major risk factors for Parkinson's disease (PD). This study examines the burden of PD in Central Asia, a region where data on neurological disorders is notably sparse.

Methods: Building on the latest Global Burden of Disease Study (GBD 2021), this study investigates the Years of Life Lost (YLLs), Years Lived with Disability (YLDs), and Disability-Adjusted Life Years (DALYs) associated with PD in Central Asia and its countries from 1990 to 2021.

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We sought to assess cardiac magnetic resonance derived left ventricular hemodynamic forces (HDF) in athletes compared to patients with hypertension. Sixty athletes and 48 hypertensive patients were studied. HDF were measured during the entire cardiac cycle, the systolic phase, suction, early LV filling, and atrial thrust.

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  • Cancer is a major health issue in Kazakhstan, with a study analyzing mortality trends from 2014 to 2022 revealing significant increases in deaths among younger individuals (ages 18-44) and variable trends in older age groups, highlighting the necessity for ongoing monitoring and targeted healthcare strategies.
  • The research utilized data from Kazakhstan's national health system, leading to findings that trachea, bronchus, lung, stomach, and colon cancers were the primary causes of mortality, representing over a third of cancer-related deaths in the period examined.
  • Notably, while overall cancer mortality rates remained stable, there were decreases in oesophageal cancer mortality and regional differences, particularly an alarming rise in mortality in the
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Tuberculosis (TB) is a highly contagious disease that remains a global concern affecting numerous countries. Kazakhstan has been facing considerable challenges in TB prevention and treatment for decades. This study aims to understand TB transmission dynamics by developing and comparing statistical and deterministic models: Seasonal Autoregressive Integrated Moving Average (SARIMA) and the basic Susceptible-Infected-Recovered (SIR).

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  • Peripheral artery disease (PAD) is a serious health issue globally, causing significant health problems and increasing mortality, prompting the need for more effective management approaches.
  • A study analyzing data from the Unified National Electronic Healthcare System (2014-2021) revealed a rising trend in PAD incidences, with 19,507 hospitalizations, predominantly affecting older adults and linked to several comorbidities.
  • The findings indicate that conditions like heart failure and acute myocardial infarction enhance mortality risks in PAD patients, reinforcing the need for urgent interventions in Kazakhstan to address this growing health concern.
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  • A study in Kazakhstan from 2014 to 2020 aimed to estimate the epidemiology of epilepsy using a comprehensive health database, focusing on incidence, prevalence, mortality, and disability-adjusted life years (DALYs).
  • The data revealed a significant increase in epilepsy cases, with incidence rising from 26.15 to 88.80 per 100,000 people and prevalence tripling within the same timeframe, while DALYs indicated a heavy disease burden.
  • Key factors like age and comorbid conditions greatly impacted mortality rates, underscoring the need for specific interventions to support affected groups, particularly children and individuals with other neurological issues.
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Chronic kidney disease (CKD) presents a significant global health challenge, often progressing to end-stage renal disease (ESRD) necessitating renal replacement therapy (RRT). Late referral (LR) to nephrologists before RRT initiation is linked with adverse outcomes. However, data on CKD diagnosis and survival post-RRT initiation in Kazakhstan remain limited.

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Cardiovascular kidney metabolic (CKM) syndrome represents a complex interplay of cardiovascular disease (CVD), chronic kidney disease (CKD), and metabolic comorbidities, posing a significant public health challenge. Gender exerts a critical influence on CKM syndrome, affecting the disease severity and onset through intricate interactions involving sex hormones and key physiological pathways such as the renin-angiotensin system, oxidative stress, inflammation, vascular disease and insulin resistance. It is widely known that beyond the contribution of traditional risk factors, men and women exhibit significant differences in CKM syndrome and its components, with distinct patterns observed in premenopausal women and postmenopausal women compared to men.

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Proteinuria poses a substantial risk for the progression of chronic kidney disease (CKD) and its related complications. Kidneys excrete hundreds of individual proteins, some with a potential impact on CKD progression or as a marker of the disease. However, the available data on specific urinary proteins and their relationship with CKD severity remain limited.

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This scoping review addresses the transformation and development of new healthcare systems in nine countries -Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Russia, Tajikistan, Turkmenistan, and Uzbekistan over the period following the collapse of the Soviet Union from 1991 to the present. This assessment focuses on maternal and child health, mental health, communicable diseases, and non-communicable diseases in an effort to highlight the changes in the healthcare status of these nine countries under scrutiny. Considering that all the post-Soviet nations are officially recognized members of the World Health Organization (WHO) and have demonstrated their commitment to attaining the WHO's objectives, the evaluation of healthcare system progress and improvement was carried out utilizing indicators provided by the WHO.

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The International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) was established to aid understanding of the status and capacity of countries to provide optimal kidney care worldwide. This report presents the current characteristics of kidney care in the ISN Newly Independent States (NIS) and Russia region. Although the median prevalence of chronic kidney disease (CKD) was higher (11.

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  • Kidney transplantation is the preferred treatment for end-stage renal disease but can lead to complications like post-transplant diabetes mellitus (PTDM), which affects patient health significantly.* -
  • PTDM develops due to factors like insulin resistance and immunosuppressive drugs; traditional diagnostic methods have limitations, with the oral glucose tolerance test being more effective in detecting early cases.* -
  • Managing PTDM poses challenges due to insufficient large-scale trial evidence, although glucose-lowering medications and lifestyle changes are primary strategies, emphasizing the need for tailored approaches to diagnosis and treatment.*
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Introduction: Renal injury is among the leading causes of morbidity and mortality; however, there are no reliable indicators for determining the likelihood of developing chronic kidney disease (CKD), CKD progression, or AKI events. Vascular growth factors called angiopoietins have a role in endothelial function, vascular remodeling, tissue stabilization, and inflammation and have been implicated as prognostic and predictive markers in AKI.

Methods: Although the exact mechanism of the relationship between kidney injury and angiopoietins is unknown, this review demonstrates that AKI patients have higher angiopoietin-2 levels and that higher angiopoietin-1 to angiopoietin-2 ratio may potentially be linked with a reduced risk of the CKD progression.

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Background: Physical activity contributes to changes in cardiac morphology, which are known as "athlete's heart". Therefore, these modifications can be characterized using different imaging modalities such as echocardiography, including Doppler (flow Doppler and Doppler myocardial imaging) and speckle-tracking, along with cardiac magnetic resonance, and cardiac computed tomography.

Main Text: Echocardiography is the most common method for assessing cardiac structure and function in athletes due to its availability, repeatability, versatility, and low cost.

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  • The study investigates tuberculosis (TB) trends in Kazakhstan from 2014 to 2019, focusing on incidence, mortality rates, and survival factors using extensive health data.
  • It found that while TB incidence decreased significantly, overall mortality rates increased, with specific demographic patterns indicating higher risk in older adults, men, urban dwellers, and patients with HIV or diabetes.
  • The research emphasizes the need for targeted health interventions based on demographic risk factors and underlines the importance of utilizing administrative health records for better public health policy in Kazakhstan.
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Proteinuria is a well-established biomarker of chronic kidney disease (CKD) and a risk predictor of associated disease outcomes. Proteinuria is also a driver of CKD progression toward end-stage kidney disease. Toxic effects of filtered proteins on proximal tubular epithelial cells enhance tubular atrophy and interstitial fibrosis.

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Aim: To perform a meta-analysis to quantify the effect of tirzepatide on blood pressure and lipids.

Methods: PubMed, Ovid/Medline, Web of Science, Scopus, Cochrane Library and CINAHL databases were screened and the randomized controlled trials evaluating the effects of tirzepatide on either blood pressure or lipid profiles were included.

Results: Seven randomized controlled trials have investigated the effects of tirzepatide on blood pressure and lipid profiles.

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Introduction: Spontaneous pregnancy loss (SPL) is a common health problem that affects 1:10 of childbearing women, and is linked with physical and psychological complications. As the number of nationwide studies on the incidence of SPL is few, especially from middle-income countries, in this study we investigated the epidemiology, complications and outcomes of SPL before 22 weeks of gestation by analyzing large-scale healthcare data from the Unified Nationwide Electronic Healthcare System (UNEHS) in Kazakhstan.

Material And Methods: A population-based study among women who experienced SPL in any healthcare setting of the Republic of Kazakhstan during the period of 2014-2019.

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Background: Cardiovascular diseases contribute to premature mortality globally, resulting in substantial social and economic burdens. The Global Burden of Disease (GBD) Study reported that in 2019 alone, heart attack and strokes accounted for the deaths of 18.6 million individuals.

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Article Synopsis
  • - This study examines the growing HIV crisis in Kazakhstan, aiming to predict infection prevalence from 2020 to 2030 using mathematical modeling and time series analysis methods.
  • - Two models, ARIMA and the Susceptible-Infected (SI) model, forecast an increase in HIV prevalence, with the SI model predicting a higher rate by 2030, while also evaluating the impact of pre-exposure prophylaxis (PrEP) on reducing rates.
  • - The findings suggest that both models are statistically significant and recommend their use for healthcare planning and resource allocation to effectively combat HIV in the region.
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