Publications by authors named "Abdushukur Ablimit"
Vasopressin-induced trafficking of aquaporin-2 (AQP2) water channels in kidney collecting duct cells is critical to regulate the urine concentration. To better understand the mechanism of subcellular trafficking of AQP2, we examined MDCK cells expressing AQP2 as a model. We first performed double-immunolabeling of AQP2 with endosomal marker proteins, and showed that AQP2 is stored at a Rab11-positive subapical compartment.
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- The study investigated the expression and localization of aquaporins, specifically AQP1 and AQP3, in the lactating rat mammary gland using techniques like RT-PCR and immunoblotting.
- AQP3 was present in the alveolar epithelium and duct system, while AQP1 was found in the capillaries and venules, indicating their specific roles in the mammary gland.
- AQP3 was not detected in virgin females, but appeared during pregnancy, suggesting these aquaporins are involved in milk synthesis and secretion during lactation.
Fluid transfer such as secretion and absorption is one of the major functions of the digestive system. Aquaporins are water channel proteins providing water transfer across the cellular membrane. At least six aquaporin isoforms are expressed in the digestive system.
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