Targeted siRNA nanotherapeutics against breast and ovarian metastatic cancer: a comprehensive review of the literature.

Metastasis is considered the major cause of unsuccessful cancer therapy. The metastatic development requires tumor cells to leave their initial site, circulate in the blood stream, acclimate to new cellular environments at a remote secondary site and endure there. There are several steps in metastasis, including invasion, intravasation, circulation, extravasation, premetastatic niche formation, micrometastasis and metastatic colonization.

Advances with antibody-drug conjugates in breast cancer treatment.

Antibody-drug conjugate-based therapy for treatment of cancer has attracted much attention because of its enhanced efficacy against numerous cancer types. Commonly, an ADC includes a mAb linked to a therapeutic payload. Antibody, linker and payload are the three main components of ADCs.

Biomedical response under visible-light irradiation promoted by new hydrothermally synthesized SiO-Zn@FeO nanofibers.

In the presence of FeO nano-fibers, we prepared SiO-Zn@FeO hybrid Nano-fibers through a novel and simple one-pot redox reaction between ZnSO & SiO. The FeO exterior nano-fibers would be homogenously covered by SiO coating to arrange a distinctive core-shell construction and then Zn nanoparticles are intercalated in the covering of SiO. The synthesized nanofibers were tested for photodegradation of methylene blue (MB).

Metal complexes of curcumin--synthetic strategies, structures and medicinal applications.

This Tutorial Review presents an overview on the synthesis, characterization and applications of metal complexes containing curcumin (=1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) and its derivatives as ligands. Innovative synthetic strategies leading to soluble and crystallizable metal curcumin complexes are outlined in detail. Special emphasis is placed on the highly promising and exciting medicinal applications of metal curcumin complexes, with the three most important areas being anticancer activity and selective cytotoxicity, anti-Alzheimer's disease activity, and antioxidative/neuroprotective effects.