Synthesis, characterization, antimicrobial, cytotoxic and carbonic anhydrase inhibition activities of multifunctional pyrazolo-1,2-benzothiazine acetamides.

The advent of antibiotic resistance in microorganisms requires the discovery and synthesis of novel antibiotics. At the same time, human pathogens are contributing to chronic and persistent inflammation. Motivated by these two concerning issues, new antibiotic drug candidates are synthesized by incorporation of benzothiazine, pyrazole, and amide moieties in a new scaffold to create multifunctional derivatives of pyrazolo-1,2-benzothiazine.

Review: Drug-induced neutropenia--pathophysiology, clinical features, and management.

Drug therapy plays a significant role in causing neutropenia. The neutropenia may be immune mediated or due to direct inhibition of the bone marrow precursors. Recently, due to wide use of chemotherapy, febrile neutropenia has become a common and devastating problem.

Recurrence of prostate adenocarcinoma presenting with multiple myeloma simulating skeletal metastases of prostate adenocarcinoma.

We present the case of a 77-year-old man with recurrence of prostate adenocarcinoma and widespread skeletal lesions. The skeletal lesions were found to be caused by multiple myeloma rather than metastatic spread of prostate adenocarcinoma. Various aspects of the radiographic imaging, evaluation of elevated prostate-specific antigen, and treatment of prostate adenocarcinoma are discussed.