Publications by authors named "Abdurrahman E Ahmad"
Article Synopsis
- * The study investigated the anticancer effects of the chloroform root extract from the herb Burm on liver cancer induced in mice using specific chemicals.
- * Results showed that the extract reduced liver enzyme toxicity, promoted apoptotic cell death in cancer cells, and significantly increased the expression of apoptotic genes, suggesting it may effectively induce apoptosis in liver cancer.
Background: Diabetic foot ulcers (DFUs) present with high morbidity and reduce patient's quality of life. There is a gross paucity of data on biofilm-producing bacteria in DFU Infection in North-Western Nigeria. The study sought to determine the biofilm-forming ability of bacteria isolates from DFUs and determine their antimicrobial susceptibility pattern in Zaria, North-Western Nigeria.
View Article and Find Full Text PDFIntroduction: the most recently discovered severe acute respiratory syndrome Coronavirus 2 (SARS-COV-2) that causes COVID-19, subjected the entire world in turmoil health-wise and economically. With higher burden of malaria in Nigeria and other sub-Saharan African countries coupled with fragile healthcare system and delivery, these may pose a threat in the diagnosis and management of COVID-19 patients co-infected with malaria. Free radicals have been implicated in the progression and pathogenesis of malaria and COVID-19 through Fenton's reaction and cytokine storm respectively.
View Article and Find Full Text PDFObjective: T-helper cells (Th)-1& -2 cytokines homeostasis control or predict clinical outcome of infected persons, especially those with HIV /AIDS. This case-control study evaluated the leucocytes differentials, TNF-alpha, interleukin (IL)-2 and -10 levels among HIV infected persons with serological evidence of leishmaniasis attending University of Abuja Teaching Hospital, Nigeria.
Materials And Methods: Blood samples from 28 HIV infected persons who had Leishmania donovani rK39 and Immunoglobulin-G (IgG) positive (group 1), 30 age- & -sex matched HIV infected persons without Leishmania antibodies (group 2) and 30 apparently healthy persons without HIV and Leishmania antibodies (group 3).
The incidence and case-fatality rates (CFRs) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, the etiological agent for Coronavirus Disease 2019 (COVID-19), have been rising unabated. Even though the entire world has been implementing infection prevention and control measures, the pandemic continues to spread. It has been widely accepted that preventive vaccination strategies are the public health measures for countering this pandemic.
View Article and Find Full Text PDFBackground: An estimated 75% of Nigerians are at risk of hepatitis B virus (HBV) exposure. In an attempt to reduce the menace, the assessment of risk factors associated with HBV infection and general perception of infected individuals is a step in that direction.
Aim Of The Study: This study, therefore, identified exposure to risk factors and general perceptions associated with HBV infection in infected individuals in Zaria, Nigeria.
Article Synopsis
- * The study reviewed data from 2002 to 2017 to analyze and compile the prevalence of various HIV-1 subtypes in Nigeria, utilizing a combination of sixteen studies for a random effect meta-analysis.
- * The findings indicated that Subtype G and CRF02_AG are the most prevalent, with pooled prevalence rates of 38.27% and 37.81%, respectively, highlighting the need for targeted HIV treatment strategies in these populations.
Evaluation of apoptotic protease-activating Factor-1 and cluster of Differentiation-4 T-Cell counts in patients-infected with mycobacterium tuberculosis in Bauchi, Nigeria.
Int J Mycobacteriol
November 2019
Background: This cross-sectional study evaluated Apoptotic Protease Activating Factor and cluster of differentiation-4 (CD4) T-cell counts in patients infected with Mycobacterium tuberculosis in Bauchi, Nigeria.
Methods: This involved 180 blood samples from 90 tuberculosis (TB)-infected patients and 90 of their close contacts at home or attending Federal Medical Center Azare and Infectious Disease Hospital Bayara, Bauchi, Nigeria. The blood samples were analyzed for Apoptotic Protease Activating Factor (Apaf-1) expression using ELISA and CD4 T cells using cyflow counter.
Article Synopsis
- Hepatitis B virus (HBV) is highly prevalent in Nigeria, with genotype E being the most common strain found in Zaria.
- A study analyzed blood samples from 165 participants to identify the HBV genotypes, revealing that 83.6% had detectable HBV DNA, mostly in mixed genotypes.
- The findings showed five HBV genotypes, with HBV/E (97.1%) as the most frequent, followed by HBV/B (82.6%), and lower rates for HBV/A, C, and D, highlighting the mixed nature of infections in the region.
Background: Individuals with human T-cell lymphotrophic virus type-1 (HTLV-1)/HIV-1 coinfection have been demonstrated to undergo CD4+ lymphocytosis even in the face of immunodeficiency and increased vulnerability to opportunistic pathogens that can lead to poor prognosis.
Objective: This study investigated the prevalence as well as the effects of HIV-1/HTLV-1 coinfection on CD4+ cell counts, routine hematology, and biochemical parameters of study participants.
Materials And Methods: This prospective cross-sectional study involved 184 blood samples collected from HIV-1-seropositive individuals attending HIV-special clinic of the University of Abuja Teaching Hospital, Gwagwalada, Nigeria.