Haematological abnormalities in systemic lupus erythematosus.

Objectives: This study was conducted to evaluate the frequency and pattern of haematological abnormalities (HA) in SLE patients at the time of diagnosis and last follow-up, and their relationship with organ involvement.

Patients And Methods: This retrospective study included patients who were diagnosed and treated for SLE from 1982 to 2008 at King Khalid University hospital, Riyadh. Demographic and haematological parameters at diagnosis and the last follow-up, disease manifestations, organ involvement and clinical hematological complications were recorded.

Lupus nephritis among 624 cases of systemic lupus erythematosus in Riyadh, Saudi Arabia.

The aim of this article is to study the prevalence, clinicolaboratory features, WHO histological types, therapy and renal outcome of lupus nephritis (LN) in Saudi Arabia. During the 27-year-period (1980-2006), 299 (47.9%) cases of LN were identified among the 624 cases of systemic lupus erythematosus (SLE) follow-up at King Khalid University Hospital, Riyadh.

A prospective study of the incidence and characteristics of septic arthritis in a teaching hospital in Riyadh, Saudi Arabia.

To find the incidence, characteristics, method of treatment, and outcome of synovial fluid culture-positive septic arthritis, all newly admitted cases of synovial fluid culture-positive septic arthritis to King Khalid University Hospital, Riyadh, Saudi Arabia were studied prospectively during August 2005 to July 2006 and only those with positive synovial fluid culture septic arthritis were included in the analysis. Demographic, clinical, hematological, biochemical, microbiological, radiological, and histopathological data along with the interventional and surgical procedures and the functional outcome related to the joint involved were recorded. Of the 42 patients admitted, only 12 fulfilled the study criteria of having positive synovial fluid culture.

Immunogenicity of singlet oxygen modified human DNA: implications for anti-DNA antibodies in systemic lupus erythematosus.

Reactive oxygen species (ROS)-modified DNA has been shown to be a better and more discriminating immunogen than native DNA (nDNA) for the production of anti-DNA autoantibodies in SLE (systemic lupus erythematosus). Among ROS, the role of hydroxyl radical (.OH) in the induction of damage and modification of nDNA has been extensively studied while such documentation implicating singlet oxygen ((1)O(2)) in inducing immunogenicity in nDNA leading to the production of anti-double-stranded (ds) DNA autoantibodies in SLE is not yet available.