Publications by authors named "Abdunaser Eadaim"
Article Synopsis
- - Clathrin-mediated endocytosis relies on a branched actin network that provides the force needed for membrane invagination, with actin capping protein (CP) playing a crucial role in regulating actin filament dynamics.
- - Recent research indicates that CP does not just bind randomly to actin but is instead regulated by specific proteins with CP-interacting (CPI) motifs, though the interplay between these proteins remains unclear.
- - The study demonstrates that two proteins, Aim21 and Bsp1, work together to recruit CP to the actin network, while another protein, twinfilin, manages CP turnover after recruitment, showcasing a coordinated approach to regulating CP in endocytosis.
Age-related changes in ion channel expression are likely to affect neuronal signaling. Here, we examine how age affects Kv4/Shal and Kv1/Shaker K+ channel protein levels in Drosophila. We show that Kv4/Shal protein levels decline sharply from 3 days to 10 days, then more gradually from 10 to 40 days after eclosion.
View Article and Find Full Text PDFHomeostatic synaptic plasticity (HSP) involves compensatory mechanisms employed by neurons and circuits to preserve signaling when confronted with global changes in activity that may occur during physiological and pathological conditions. Cholinergic neurons, which are especially affected in some pathologies, have recently been shown to exhibit HSP mediated by nicotinic acetylcholine receptors (nAChRs). In Drosophila central neurons, pharmacological blockade of activity induces a homeostatic response mediated by the Drosophila α7 (Dα7) nAChR, which is tuned by a subsequent increase in expression of the voltage-dependent K4/Shal channel.
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