Publications by authors named "Abdulrazaq Bidemi Nafiu"
Article Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons, leading to both motor and non-motor symptoms that impact patients' quality of life and society.
- Various factors contribute to the progression of PD, such as oxidative stress and mitochondrial dysfunction, prompting interest in alternative treatments like nutrition and plant extracts alongside traditional pharmacological therapies.
- The review analyzes evidence showing how certain dietary compounds and nutraceuticals may provide protective benefits for PD by improving mitochondrial function and reducing inflammation, while also discussing challenges in applying these findings to clinical practice.
L-DOPA, the gold standard for managing Parkinson's disease (PD) is fraught by motor fluctuations termed L-Dopa-Induced Dyskinesia (LID). LID has very few therapeutic options. Hence, the need for preclinical screening of new interventions.
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- The study explored how selenium (Se) might help reduce pain from MPTP-induced neurotoxicity in Swiss mice.
- Seven days post-MPTP injection, various treatment groups were compared, including those receiving DOPA and different dosages of Se, to assess their effects on motor coordination and pain responses.
- Results showed that while both Se and DOPA improved motor activity and pain thresholds, Se also decreased levels of pro-inflammatory cytokines and helped regulate pain biomarkers in the brain, indicating its potential as a pain-relieving supplement that needs further investigation.
Neurobehavioral, neurochemical and synaptic plasticity perturbations during postnatal life of rats exposed to chloroquine in-utero.
Neurotoxicol Teratol
January 2022
Despite reports that quinoline antimalarials including chloroquine (Chq) exhibit idiosyncratic neuropsychiatric effects even at low doses, the drug continues to be in widespread use during pregnancy. Surprisingly, very few studies have examined the potential neurotoxic action of Chq exposure at different points of gestation or how this phenomenon may affect neurophysiological well-being in later life. We therefore studied behavior, and the expression of specific genes and neurochemicals modulating crucial neural processes in offspring of rats exposed to prophylactic dose of Chq during different stages of gestation.
View Article and Find Full Text PDF: L-DOPA, the predominant therapy for Parkinson's disease (PD) is associated with motor deficits after prolonged use. The nigrostriatal tract, a primary target of neurodegeneration in PD, contains abundant Vitamin-D receptors, suggesting a potential role for VD in the disease. Therefore, we tested the impact of Vitamin D3 (VD3) in a mouse model of PD.
View Article and Find Full Text PDFBackground: Nature and size of rodent cages vary from one laboratory or country to another. Little is however known about the physiological implications of exposure to diverse cage sizes in animal-based experiments.
Method: Here, two groups of male Swiss mice (Control group - Cage stationed, and Test group - Cage migrated) were used for this study.
Background: Increased wound healing efficiency by Se(2+) added Carica papaya L. (Caricaceae) fruit extract was linked to increased antioxidant and anti-inflammatory responses during healing. We investigated the impact of Se(2+) or Zn(2+) added papaya water (WE) and phosphate-buffered saline (PE) extracts on cells recruitment and bio-molecular alterations on days 4 and 10 post wounding in an in vivo excision wound.
View Article and Find Full Text PDFContext: Carica papaya L. (Caricaceae) fruit was shown to exhibit wound healing properties.
Objectives: We investigated anti-inflammatory and antioxidant potential of papaya fruit phosphate-buffered saline extract (PE) during wound healing and enhancement of the potentials due to trace ions addition.