Synthesis of new coumarin derivatives and assessment of their antimicrobial efficacy.

Aim: Developing new antimicrobial agents in response to the urgent challenge of antimicrobial resistance.

Methods: Synthesis of the targeted coumarins, elucidation of their structures using spectroscopic tools, and investigation of their antimicrobial activity.

Results: Coumarin-pyrazole with CF in the 3-position of the pyrazole ring displayed the lowest minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) with values of 1.